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ABCB11 ATP binding cassette subfamily B member 11 [ Canis lupus familiaris (dog) ]

Gene ID: 488390, updated on 17-Aug-2024

Summary

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Official Symbol
ABCB11provided by VGNC
Official Full Name
ATP binding cassette subfamily B member 11provided by VGNC
Primary source
VGNC:VGNC:37433
See related
Ensembl:ENSCAFG00845020713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
BSEP; Abcb11e
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 36
Exon count:
29
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (13859241..13951551, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (13757951..13834638, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (14048864..14125753, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (13948052..14024630, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (13935894..14012502, complement)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene SPC25 component of NDC80 kinetochore complex Neighboring gene glucose-6-phosphatase catalytic subunit 2 Neighboring gene ATP synthase membrane subunit DAPIT, mitochondrial-like Neighboring gene dehydrogenase/reductase 9 Neighboring gene LDL receptor related protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins. Yabuuchi H, et al. Biopharm Drug Dispos, 2008 Nov. PMID 18985798
  2. Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11). Kato T, et al. Biochim Biophys Acta, 2010 Sep. PMID 20398791
  3. LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. Homolya L, et al. PLoS One, 2014. PMID 24643070, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dog Bsep shows similar ATP-dependent bile acid transport characteristics to human BSEP and rat Bsep.
    Title: Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bile salt export pump

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143932.1 → NP_001137404.1  bile salt export pump

    See identical proteins and their annotated locations for NP_001137404.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ157431
    UniProtKB/Swiss-Prot
    B8K1W2
    UniProtKB/TrEMBL
    A0A8P0NPM9
    Related
    ENSCAFP00845028888.1, ENSCAFT00845036897.1
    Conserved Domains (1) summary
    PTZ00265
    Location:29 → 1318
    PTZ00265; multidrug resistance protein (mdr1); Provisional

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    13859241..13951551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038446708.1 → XP_038302636.1  bile salt export pump isoform X1

    UniProtKB/Swiss-Prot
    B8K1W2
    UniProtKB/TrEMBL
    A0A8P0NPM9
    Related
    ENSCAFP00845028736.1, ENSCAFT00845036706.1
    Conserved Domains (1) summary
    PTZ00265
    Location:29 → 1318
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  2. XM_038446709.1 → XP_038302637.1  bile salt export pump isoform X2

    UniProtKB/TrEMBL
    A0A8C0JP75
    Conserved Domains (1) summary
    PTZ00265
    Location:87 → 1257
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  3. XM_038446710.1 → XP_038302638.1  bile salt export pump isoform X3

    Conserved Domains (2) summary
    cd03249
    Location:677 → 916
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:2 → 913
    PTZ00265; multidrug resistance protein (mdr1); Provisional

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    13948052..14024630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    13935894..14012502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    14048864..14125753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    13757951..13834638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B8K1W2.1 GenPept UniProtKB/Swiss-Prot:B8K1W2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.