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SI sucrase-isomaltase [ Canis lupus familiaris (dog) ]

Gene ID: 488141, updated on 25-Jul-2026
Official Symbol
SIprovided by VGNC
Official Full Name
sucrase-isomaltaseprovided by VGNC
Primary source
VGNC:VGNC:46161
See related
Ensembl:ENSCAFG00845017677 RGD:12366798
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Location:
chromosome: 34
Exon count:
48
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 34 NC_051838.1 (30347263..30435400, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 34 NC_006616.4 (39346430..39434804, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 34 NC_049255.1 (30511922..30599883, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 34 NC_049294.1 (30290443..30378872, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 34 NC_049775.1 (30241911..30330433, complement)

Chromosome 34 - NC_051838.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC111093947 Neighboring gene peroxiredoxin-5, mitochondrial-like Neighboring gene SLIT and NTRK like family member 3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables alpha-1,4-glucosidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
sucrase-isomaltase, intestinal
XP_005639937.1
XP_038301362.1
XP_038301363.1
XP_038376278.1
XP_038376279.1
XP_038439206.1
XP_038439207.1
XP_038503614.1
XP_038503615.1
XP_545265.3

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051838.1 Reference ROS_Cfam_1.0

    Range
    30347263..30435400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038445434.1 → XP_038301362.1  sucrase-isomaltase, intestinal isoform X1

    UniProtKB/TrEMBL
    A0A8C0L9Z2, A0A8I3P4Z5
    Related
    ENSCAFP00845024530.1, ENSCAFT00845031334.1
    Conserved Domains (6) summary
    smart00018
    Location:934 → 978
    PD; P or trefoil or TFF domain
    cd06602
    Location:343 → 707
    GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
    cd14752
    Location:227 → 343
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam00088
    Location:70 → 108
    Trefoil; Trefoil (P-type) domain
    pfam01055
    Location:1194 → 1689
    Glyco_hydro_31; Glycosyl hydrolases family 31
    pfam16863
    Location:125 → 234
    NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

  2. XM_038445435.1 → XP_038301363.1  sucrase-isomaltase, intestinal isoform X2

    UniProtKB/TrEMBL
    A0A8C0L9Z2
    Conserved Domains (6) summary
    smart00018
    Location:845 → 889
    PD; P or trefoil or TFF domain
    cd06602
    Location:254 → 618
    GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
    cd14752
    Location:138 → 254
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam00088
    Location:2 → 19
    Trefoil; Trefoil (P-type) domain
    pfam01055
    Location:1105 → 1600
    Glyco_hydro_31; Glycosyl hydrolases family 31
    pfam16863
    Location:36 → 145
    NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049294.1 Alternate UMICH_Zoey_3.1

    Range
    30290443..30378872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038520350.1 → XP_038376278.1  

  2. XM_038520351.1 → XP_038376279.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049775.1 Alternate UNSW_CanFamBas_1.0

    Range
    30241911..30330433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038647686.1 → XP_038503614.1  

  2. XM_038647687.1 → XP_038503615.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049255.1 Alternate UU_Cfam_GSD_1.0

    Range
    30511922..30599883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038583278.1 → XP_038439206.1  sucrase-isomaltase, intestinal isoform X1

    UniProtKB/TrEMBL
    A0A8C0L9Z2

  2. XM_038583279.1 → XP_038439207.1  sucrase-isomaltase, intestinal isoform X2

    UniProtKB/TrEMBL
    A0A8C0L9Z2

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    39346430..39434804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_545265.7 → XP_545265.3  sucrase-isomaltase, intestinal isoform X1

    UniProtKB/TrEMBL
    A0A8C0L9Z2
    Conserved Domains (7) summary
    smart00018
    Location:934 → 978
    PD; P or trefoil or TFF domain
    COG1501
    Location:134 → 887
    YicI; Alpha-glucosidase, glycosyl hydrolase family GH31 [Carbohydrate transport and metabolism]
    cd06602
    Location:343 → 707
    GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
    cd14752
    Location:1099 → 1213
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam00088
    Location:63 → 108
    Trefoil; Trefoil (P-type) domain
    pfam01055
    Location:1194 → 1689
    Glyco_hydro_31; Glycosyl hydrolases family 31
    pfam16863
    Location:993 → 1106
    NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

  2. XM_005639880.4 → XP_005639937.1  sucrase-isomaltase, intestinal isoform X2

    UniProtKB/TrEMBL
    A0A8C0L9Z2
    Conserved Domains (7) summary
    smart00018
    Location:845 → 889
    PD; P or trefoil or TFF domain
    COG1501
    Location:45 → 798
    YicI; Alpha-glucosidase, glycosyl hydrolase family GH31 [Carbohydrate transport and metabolism]
    cd06602
    Location:254 → 618
    GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
    cd14752
    Location:1010 → 1124
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam00088
    Location:2 → 19
    Trefoil; Trefoil (P-type) domain
    pfam01055
    Location:1105 → 1600
    Glyco_hydro_31; Glycosyl hydrolases family 31
    pfam16863
    Location:904 → 1017
    NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
Nucleotide Protein
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