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NPR1 natriuretic peptide receptor 1 [ Homo sapiens (human) ]

Gene ID: 4881, updated on 4-Oct-2020

Summary

Official Symbol
NPR1provided by HGNC
Official Full Name
natriuretic peptide receptor 1provided by HGNC
Primary source
HGNC:HGNC:7943
See related
Ensembl:ENSG00000169418 MIM:108960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANPa; NPRA; ANPRA; GUC2A; GUCY2A
Summary
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
Expression
Biased expression in fat (RPKM 49.0), lung (RPKM 10.4) and 9 other tissues See more
Orthologs

Genomic context

See NPR1 in Genome Data Viewer
Location:
1q21.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153678649..153693992)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153651093..153666468)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SNAP associated protein Neighboring gene tRNA-iMet (anticodon CAT) 1-1 Neighboring gene interleukin enhancer binding factor 2 Neighboring gene microRNA 8083 Neighboring gene gem nuclear organelle associated protein 2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 372, pseudogene Neighboring gene integrator complex subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled peptide receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
natriuretic peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
natriuretic peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
body fluid secretion TAS
Traceable Author Statement
more info
PubMed 
cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of renal sodium excretion TAS
Traceable Author Statement
more info
PubMed 
positive regulation of urine volume TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor guanylyl cyclase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood pressure NAS
Non-traceable Author Statement
more info
PubMed 
regulation of blood vessel diameter NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
regulation of vascular permeability TAS
Traceable Author Statement
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
atrial natriuretic peptide receptor 1
Names
ANP-A
ANPR-A
GC-A
NPR-A
atrial natriuretic peptide receptor type A
atrionatriuretic peptide receptor A
guanylate cyclase A
natriuretic peptide A type receptor
natriuretic peptide receptor A
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
testicular tissue protein Li 20
NP_000897.3
XP_005245275.1
XP_016856863.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000906.4NP_000897.3  atrial natriuretic peptide receptor 1 precursor

    See identical proteins and their annotated locations for NP_000897.3

    Status: VALIDATED

    Source sequence(s)
    AK025024
    Consensus CDS
    CCDS1051.1
    UniProtKB/Swiss-Prot
    P16066
    UniProtKB/TrEMBL
    A0A140VJE6
    Related
    ENSP00000357669.3, ENST00000368680.4
    Conserved Domains (7) summary
    cd06385
    Location:36443
    PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
    smart00219
    Location:547801
    TyrKc; Tyrosine kinase, catalytic domain
    smart00044
    Location:8401032
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:534807
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:8671053
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:54414
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:816861
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153678649..153693992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245218.2XP_005245275.1  atrial natriuretic peptide receptor 1 isoform X1

    Conserved Domains (6) summary
    cd06385
    Location:36443
    PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
    smart00044
    Location:8141006
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:534781
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:8411027
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:54414
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:790835
    HNOBA; Heme NO binding associated
  2. XM_017001374.2XP_016856863.1  atrial natriuretic peptide receptor 1 isoform X2

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