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PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Canis lupus familiaris (dog) ]

Gene ID: 488084, updated on 3-Oct-2020

Summary

Official Symbol
PIK3CAprovided by VGNC
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:44555
See related
Ensembl:ENSCAFG00000011212
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs

Genomic context

See PIK3CA in Genome Data Viewer
Location:
chromosome: 34
Exon count:
21
Annotation release Status Assembly Chr Location
105 current CanFam3.1 (GCF_000002285.3) 34 NC_006616.3 (12600140..12681905)

Chromosome 34 - NC_006616.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093927 Neighboring gene zinc finger matrin-type 3 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3 Neighboring gene uncharacterized LOC111093910

Genomic regions, transcripts, and products

Genomic Sequence:
NC_006616.3 Chromosome 34 Reference CanFam3.1 Primary Assembly

Pathways from PubChem

General gene information

Markers

Homology

General protein information

Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Names
phosphoinositide-3-kinase, catalytic, alpha polypeptide
XP_022270060.1
XP_545208.2

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CanFam3.1 Primary Assembly

Genomic

  1. NC_006616.3 Reference CanFam3.1 Primary Assembly

    Range
    12600140..12681905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_545208.6XP_545208.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    See identical proteins and their annotated locations for XP_545208.2

    UniProtKB/TrEMBL
    F1Q3M8
    Related
    ENSCAFP00000016537.4, ENSCAFT00000017863.4
    Conserved Domains (5) summary
    cd08398
    Location:325484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    cd00872
    Location:525696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05175
    Location:6951064
    PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
    pfam00794
    Location:173292
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  2. XM_022414352.1XP_022270060.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Related
    ENSCAFP00000048355.1, ENSCAFT00000080543.1
    Conserved Domains (5) summary
    cd08398
    Location:325484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    cd00872
    Location:525696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05175
    Location:6951064
    PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
    pfam00794
    Location:173292
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
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