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NPPC natriuretic peptide C [ Homo sapiens (human) ]

Gene ID: 4880, updated on 21-Dec-2019

Summary

Official Symbol
NPPCprovided by HGNC
Official Full Name
natriuretic peptide Cprovided by HGNC
Primary source
HGNC:HGNC:7941
See related
Ensembl:ENSG00000163273 MIM:600296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNP; CNP2
Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
Annotation information
Note: CNP (Gene ID: 1267) and NPPC (Gene ID: 4880) share the CNP symbol/alias in common. CNP is a widely used alternative name for C-type natriuretic peptide (NPPC), which can be confused with the official symbol for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP). [06 Jul 2018]
Expression
Biased expression in prostate (RPKM 1.1), esophagus (RPKM 0.4) and 9 other tissues See more
Orthologs

Genomic context

See NPPC in Genome Data Viewer
Location:
2q37.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (231921809..231926405, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232786805..232791038, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene guanidinoacetate N-methyltransferase pseudogene 1 Neighboring gene microRNA 1471 Neighboring gene DIS3 like 3'-5' exoribonuclease 2 Neighboring gene microRNA 562 Neighboring gene NRBF2 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
growth plate cartilage chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
growth plate cartilage chondrocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of meiotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of oocyte maturation IDA
Inferred from Direct Assay
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
protein folding IDA
Inferred from Direct Assay
more info
PubMed 
receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor guanylyl cyclase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
reproductive process IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-type natriuretic peptide
Names
natriuretic peptide precursor type C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024409.4NP_077720.1  C-type natriuretic peptide preproprotein

    See identical proteins and their annotated locations for NP_077720.1

    Status: REVIEWED

    Source sequence(s)
    AC013435, D20847, DR003533, JF420840
    Consensus CDS
    CCDS2489.1
    UniProtKB/Swiss-Prot
    P23582
    UniProtKB/TrEMBL
    E5LCN7
    Related
    ENSP00000387159.1, ENST00000409852.2
    Conserved Domains (1) summary
    pfam00212
    Location:96126
    ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    231921809..231926405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511245.3XP_011509547.1  C-type natriuretic peptide isoform X1

    See identical proteins and their annotated locations for XP_011509547.1

    UniProtKB/Swiss-Prot
    P23582
    Conserved Domains (1) summary
    pfam00212
    Location:96126
    ANP; Atrial natriuretic peptide
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