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TIAM1 TIAM Rac1 associated GEF 1 [ Canis lupus familiaris (dog) ]

Gene ID: 487731, updated on 5-Mar-2024

Summary

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Official Symbol
TIAM1provided by VGNC
Official Full Name
TIAM Rac1 associated GEF 1provided by VGNC
Primary source
VGNC:VGNC:56122
See related
Ensembl:ENSCAFG00845021944
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 31
Exon count:
33
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 31 NC_051835.1 (26177246..26558745, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 31 NC_006613.4 (26051519..26432492, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 31 NC_049252.1 (26641221..27022148, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 31 NC_049291.1 (26123696..26504723, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 31 NC_049772.1 (26135327..26516773, complement)

Chromosome 31 - NC_051835.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093556 Neighboring gene uncharacterized LOC119867051 Neighboring gene keratin associated protein 11-1 Neighboring gene uncharacterized LOC119867106 Neighboring gene U6 spliceosomal RNA Neighboring gene superoxide dismutase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions. Guillemot L, et al. Mol Biol Cell, 2008 Oct. PMID 18653465, Free PMC Article
  2. Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Chen X, et al. Nat Cell Biol, 2005 Mar. PMID 15723052

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions
    Title: Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.
  2. Par-3 has a role in tight junction assembly through the Rac exchange factor Tiam1
    Title: Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
T-lymphoma invasion and metastasis-inducing protein 1
Names
T cell lymphoma invasion and metastasis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051835.1 Reference ROS_Cfam_1.0

    Range
    26177246..26558745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038443333.1 → XP_038299261.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Related
    ENSCAFP00845030801.1, ENSCAFT00845039314.1
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  2. XM_038443334.1 → XP_038299262.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  3. XM_038443335.1 → XP_038299263.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  4. XM_038443332.1 → XP_038299260.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  5. XM_038443336.1 → XP_038299264.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

    Conserved Domains (6) summary
    smart00325
    Location:730 → 919
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:532 → 611
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:118 → 244
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:921 → 1092
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:452 → 521
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:258 → 355
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  6. XM_038443337.1 → XP_038299265.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0N581, A0A8C0R8A0, A0A8I3PFD3
    Related
    ENSCAFP00845031192.1, ENSCAFT00845039828.1
    Conserved Domains (2) summary
    smart00325
    Location:77 → 266
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:268 → 439
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049291.1 Alternate UMICH_Zoey_3.1

    Range
    26123696..26504723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038517753.1 → XP_038373681.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  2. XM_038517752.1 → XP_038373680.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  3. XM_038517754.1 → XP_038373682.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  4. XM_038517750.1 → XP_038373678.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  5. XM_038517755.1 → XP_038373683.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

    Conserved Domains (6) summary
    smart00325
    Location:730 → 919
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:532 → 611
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:118 → 244
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:921 → 1092
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:452 → 521
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:258 → 355
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  6. XM_038517756.1 → XP_038373684.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X3

    Conserved Domains (2) summary
    smart00325
    Location:77 → 266
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:268 → 439
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049772.1 Alternate UNSW_CanFamBas_1.0

    Range
    26135327..26516773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038645710.1 → XP_038501638.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  2. XM_038645711.1 → XP_038501639.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  3. XM_038645712.1 → XP_038501640.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  4. XM_038645709.1 → XP_038501637.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  5. XM_038645713.1 → XP_038501641.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

    Conserved Domains (6) summary
    smart00325
    Location:730 → 919
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:532 → 611
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:118 → 244
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:921 → 1092
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:452 → 521
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:258 → 355
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  6. XM_038645714.1 → XP_038501642.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X3

    Conserved Domains (2) summary
    smart00325
    Location:77 → 266
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:268 → 439
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049252.1 Alternate UU_Cfam_GSD_1.0

    Range
    26641221..27022148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038581329.1 → XP_038437257.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  2. XM_038581328.1 → XP_038437256.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  3. XM_038581330.1 → XP_038437258.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  4. XM_038581327.1 → XP_038437255.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  5. XM_038581331.1 → XP_038437259.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

    Conserved Domains (6) summary
    smart00325
    Location:730 → 919
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:532 → 611
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:118 → 244
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:921 → 1092
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:452 → 521
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:258 → 355
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  6. XM_038581332.1 → XP_038437260.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0N581, A0A8C0R8A0, A0A8I3PFD3
    Conserved Domains (2) summary
    smart00325
    Location:77 → 266
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:268 → 439
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006613.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26051519..26432492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005638823.4 → XP_005638880.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005638880.1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  2. XM_005638821.4 → XP_005638878.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005638878.1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  3. XM_014109762.3 → XP_013965237.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  4. XM_544855.7 → XP_544855.2  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_544855.2

    UniProtKB/TrEMBL
    A0A8C0LQF8, A0A8C0NCJ6, A0A8I3PNQ8
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  5. XM_038461683.1 → XP_038317611.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

    Conserved Domains (6) summary
    smart00325
    Location:730 → 919
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:532 → 611
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:118 → 244
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:921 → 1092
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:452 → 521
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:258 → 355
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  6. XM_022413344.2 → XP_022269052.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0N581, A0A8C0R8A0, A0A8I3PFD3
    Conserved Domains (2) summary
    smart00325
    Location:77 → 266
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:268 → 439
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
Nucleotide Protein
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