U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SMAD6 SMAD family member 6 [ Canis lupus familiaris (dog) ]

Gene ID: 487612, updated on 25-Jul-2026
Official Symbol
SMAD6provided by VGNC
Official Full Name
SMAD family member 6provided by VGNC
Primary source
VGNC:VGNC:46523
See related
Ensembl:ENSCAFG00845016415 RGD:12413314
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SMAD6 in Genome Data Viewer
Location:
chromosome: 30
Exon count:
4
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (31135483..31212132)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (30868681..30945004)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (31365990..31442355)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (31064510..31140721)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (31124002..31200323)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene zwilch kinetochore protein Neighboring gene lactase like Neighboring gene uncharacterized LOC111093334 Neighboring gene uncharacterized LOC119866923 Neighboring gene uncharacterized LOC111093346 Neighboring gene SMAD family member 3 Neighboring gene uncharacterized LOC119866924

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription regulator inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
mothers against decapentaplegic homolog 6

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    31135483..31212132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038442722.1 → XP_038298650.1  mothers against decapentaplegic homolog 6

    UniProtKB/TrEMBL
    A0A8C0K754, A0A8I3P2D1, A0A8I3P851
    Related
    ENSCAFP00845022942.1, ENSCAFT00845029172.1
    Conserved Domains (2) summary
    cd10493
    Location:161 → 274
    MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6
    cd10499
    Location:323 → 497
    MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    31064510..31140721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038517159.1 → XP_038373087.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    31124002..31200323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038645105.1 → XP_038501033.1  

    Conserved Domains (2) summary
    cd10493
    Location:161 → 274
    MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6
    cd10499
    Location:323 → 497
    MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    31365990..31442355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038580787.1 → XP_038436715.1  mothers against decapentaplegic homolog 6

    UniProtKB/TrEMBL
    A0A8I3P851

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    30868681..30945004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_544737.8 → XP_544737.3  mothers against decapentaplegic homolog 6

    UniProtKB/TrEMBL
    A0A8I3P851
    Conserved Domains (2) summary
    cd10493
    Location:162 → 275
    MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6
    cd10499
    Location:324 → 498
    MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.