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NRG2 neuregulin 2 [ Canis lupus familiaris (dog) ]

Gene ID: 487158, updated on 25-Jul-2026
Official Symbol
NRG2provided by VGNC
Official Full Name
neuregulin 2provided by VGNC
Primary source
VGNC:VGNC:43968
See related
RGD:12362760
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See NRG2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (35540482..35786931, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (32188379..32434387, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (34211046..34457510, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (32592831..32839160, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (33459495..33706597, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111091843 Neighboring gene pleckstrin and Sec7 domain containing 2 Neighboring gene uncharacterized LOC102153686 Neighboring gene uncharacterized LOC102153901 Neighboring gene uncharacterized LOC111091855 Neighboring gene purine rich element binding protein A Neighboring gene endothelial differentiation-related factor 1-like Neighboring gene cysteine rich transmembrane module containing 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
pro-neuregulin-2, membrane-bound isoform

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    35540482..35786931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038658607.1 → XP_038514535.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  2. XM_038658610.1 → XP_038514538.1  pro-neuregulin-2, membrane-bound isoform isoform X4

    UniProtKB/TrEMBL
    A0A8C0JNW9
    Conserved Domains (2) summary
    pfam02158
    Location:373 → 783
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  3. XM_038658609.1 → XP_038514537.1  pro-neuregulin-2, membrane-bound isoform isoform X3

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA03099
    Location:338 → 426
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam02158
    Location:433 → 843
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  4. XM_038658605.1 → XP_038514533.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  5. XM_038658608.1 → XP_038514536.1  pro-neuregulin-2, membrane-bound isoform isoform X2

    UniProtKB/TrEMBL
    A0A8C0JNW9
    Conserved Domains (2) summary
    pfam02158
    Location:439 → 849
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  6. XM_038658606.1 → XP_038514534.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    32592831..32839160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038469550.1 → XP_038325478.1  

    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  2. XM_038469553.1 → XP_038325481.1  

    Conserved Domains (2) summary
    pfam02158
    Location:373 → 783
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  3. XM_038469552.1 → XP_038325480.1  

    Conserved Domains (3) summary
    PHA03099
    Location:338 → 426
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam02158
    Location:433 → 843
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  4. XM_038469548.1 → XP_038325476.1  

    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  5. XM_038469551.1 → XP_038325479.1  

    Conserved Domains (2) summary
    pfam02158
    Location:439 → 849
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  6. XM_038469549.1 → XP_038325477.1  

    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    33459495..33706597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038594560.1 → XP_038450488.1  

    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  2. XM_038594564.1 → XP_038450492.1  

    Conserved Domains (2) summary
    pfam02158
    Location:373 → 783
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  3. XM_038594563.1 → XP_038450491.1  

    Conserved Domains (3) summary
    PHA03099
    Location:338 → 426
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam02158
    Location:433 → 843
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  4. XM_038594558.1 → XP_038450486.1  

    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  5. XM_038594561.1 → XP_038450489.1  

    Conserved Domains (2) summary
    pfam02158
    Location:439 → 849
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  6. XM_038594559.1 → XP_038450487.1  

    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    34211046..34457510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038530313.1 → XP_038386241.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  2. XM_038530316.1 → XP_038386244.1  pro-neuregulin-2, membrane-bound isoform isoform X4

    UniProtKB/TrEMBL
    A0A8C0JNW9
    Conserved Domains (2) summary
    pfam02158
    Location:373 → 783
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  3. XM_038530315.1 → XP_038386243.1  pro-neuregulin-2, membrane-bound isoform isoform X3

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA03099
    Location:338 → 426
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam02158
    Location:433 → 843
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  4. XM_038530311.1 → XP_038386239.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  5. XM_038530314.1 → XP_038386242.1  pro-neuregulin-2, membrane-bound isoform isoform X2

    UniProtKB/TrEMBL
    A0A8C0JNW9
    Conserved Domains (2) summary
    pfam02158
    Location:439 → 849
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  6. XM_038530312.1 → XP_038386240.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    32188379..32434387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022408389.2 → XP_022264097.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  2. XM_038457906.1 → XP_038313834.1  pro-neuregulin-2, membrane-bound isoform isoform X4

    UniProtKB/TrEMBL
    A0A8C0JNW9
    Conserved Domains (2) summary
    pfam02158
    Location:373 → 783
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  3. XM_038457900.1 → XP_038313828.1  pro-neuregulin-2, membrane-bound isoform isoform X3

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA03099
    Location:338 → 426
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam02158
    Location:433 → 843
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  4. XM_038457890.1 → XP_038313818.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  5. XM_022408390.2 → XP_022264098.1  pro-neuregulin-2, membrane-bound isoform isoform X2

    UniProtKB/TrEMBL
    A0A8C0JNW9
    Conserved Domains (2) summary
    pfam02158
    Location:439 → 849
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  6. XM_038457893.1 → XP_038313821.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF2
    Conserved Domains (3) summary
    PHA02887
    Location:352 → 395
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:441 → 851
    Neuregulin; Neuregulin family
    cd05750
    Location:246 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins
Nucleotide Protein
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