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PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [ Canis lupus familiaris (dog) ]

Gene ID: 487139, updated on 5-Mar-2024

Summary

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Official Symbol
PFKFB3provided by VGNC
Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3provided by VGNC
Primary source
VGNC:VGNC:44444
See related
Ensembl:ENSCAFG00845001712
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (30098553..30184947, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (26748126..26834516, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (28751303..28837993, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (27195708..27282045, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (28031490..28118114, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102154496 Neighboring gene protein kinase C theta Neighboring gene nucleotide triphosphate diphosphatase NUDT15-like Neighboring gene uncharacterized LOC111091659 Neighboring gene RNA binding motif protein 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 6-phosphofructo-2-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fructose 2,6-bisphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fructose metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    30098553..30184947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038658480.1 → XP_038514408.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I3MJ72, A0A8P0PAC3
    Conserved Domains (2) summary
    pfam00300
    Location:243 → 429
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:21 → 240
    6PF2K; 6-phosphofructo-2-kinase

  2. XM_038658478.1 → XP_038514406.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M0C4
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_038658483.1 → XP_038514411.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X6

    UniProtKB/TrEMBL
    A0A8C0LUT1, A0A8I3MJ72, A0A8I3MQH6, A0A8P0PAC3
    Related
    ENSCAFP00845002390.1, ENSCAFT00845002999.1
    Conserved Domains (2) summary
    pfam00300
    Location:229 → 415
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:4 → 226
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_038658484.1 → XP_038514412.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X7

    UniProtKB/TrEMBL
    A0A8C0M4L5
    Conserved Domains (2) summary
    pfam00300
    Location:210 → 396
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 207
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_038658479.1 → XP_038514407.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0M0C4, A0A8C0RA55, A0A8I3MIP6
    Related
    ENSCAFP00845002454.1, ENSCAFT00845003072.1
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_038658481.1 → XP_038514409.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X4

    UniProtKB/TrEMBL
    A0A8C0M0C4, A0A8C0PS00
    Related
    ENSCAFP00845002416.1, ENSCAFT00845003026.1
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  7. XM_038658482.1 → XP_038514410.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X5

    UniProtKB/TrEMBL
    A0A8C0M0C4, A0A8C0Q3M0, A0A8I3MZX9
    Related
    ENSCAFP00845002483.1, ENSCAFT00845003114.1
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    27195708..27282045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038469427.1 → XP_038325355.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X3

    Conserved Domains (2) summary
    pfam00300
    Location:243 → 429
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:21 → 240
    6PF2K; 6-phosphofructo-2-kinase

  2. XM_038469425.1 → XP_038325353.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X1

    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_038469430.1 → XP_038325358.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X6

    Conserved Domains (2) summary
    pfam00300
    Location:229 → 415
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:4 → 226
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_038469431.1 → XP_038325359.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X7

    Conserved Domains (2) summary
    pfam00300
    Location:210 → 396
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 207
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_038469426.1 → XP_038325354.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2

    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_038469428.1 → XP_038325356.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X4

    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  7. XM_038469429.1 → XP_038325357.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X5

    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    28031490..28118114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038594435.1 → XP_038450363.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X3

    Conserved Domains (2) summary
    pfam00300
    Location:243 → 429
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:21 → 240
    6PF2K; 6-phosphofructo-2-kinase

  2. XM_038594433.1 → XP_038450361.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X1

    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_038594438.1 → XP_038450366.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X6

    Conserved Domains (2) summary
    pfam00300
    Location:229 → 415
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:4 → 226
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_038594439.1 → XP_038450367.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X7

    Conserved Domains (2) summary
    pfam00300
    Location:210 → 396
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 207
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_038594434.1 → XP_038450362.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2

    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_038594436.1 → XP_038450364.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X4

    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  7. XM_038594437.1 → XP_038450365.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X5

    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    28751303..28837993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038530184.1 → XP_038386112.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I3MJ72, A0A8P0PAC3
    Conserved Domains (2) summary
    pfam00300
    Location:243 → 429
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:21 → 240
    6PF2K; 6-phosphofructo-2-kinase

  2. XM_038530182.1 → XP_038386110.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M0C4
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_038530188.1 → XP_038386116.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X6

    UniProtKB/TrEMBL
    A0A8C0LUT1, A0A8I3MJ72, A0A8I3MQH6, A0A8P0PAC3
    Conserved Domains (2) summary
    pfam00300
    Location:229 → 415
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:4 → 226
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_038530189.1 → XP_038386117.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X7

    UniProtKB/TrEMBL
    A0A8C0M4L5
    Conserved Domains (2) summary
    pfam00300
    Location:210 → 396
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 207
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_038530183.1 → XP_038386111.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0M0C4, A0A8C0RA55, A0A8I3MIP6
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_038530185.1 → XP_038386113.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X4

    UniProtKB/TrEMBL
    A0A8C0M0C4, A0A8C0PS00
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  7. XM_038530187.1 → XP_038386115.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X5

    UniProtKB/TrEMBL
    A0A8C0M0C4, A0A8C0Q3M0, A0A8I3MZX9
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26748126..26834516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038457446.1 → XP_038313374.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I3MJ72, A0A8P0PAC3
    Conserved Domains (2) summary
    pfam00300
    Location:243 → 429
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:21 → 240
    6PF2K; 6-phosphofructo-2-kinase

  2. XM_038457444.1 → XP_038313372.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M0C4
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_038457452.1 → XP_038313380.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X6

    UniProtKB/TrEMBL
    A0A8C0LUT1, A0A8I3MJ72, A0A8I3MQH6, A0A8P0PAC3
    Conserved Domains (2) summary
    pfam00300
    Location:229 → 415
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:4 → 226
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_038457453.1 → XP_038313381.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X7

    UniProtKB/TrEMBL
    A0A8C0M4L5
    Conserved Domains (2) summary
    pfam00300
    Location:210 → 396
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 207
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_038457445.1 → XP_038313373.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0M0C4, A0A8C0RA55, A0A8I3MIP6
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_038457450.1 → XP_038313378.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X4

    UniProtKB/TrEMBL
    A0A8C0M0C4, A0A8C0PS00
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  7. XM_038457451.1 → XP_038313379.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X5

    UniProtKB/TrEMBL
    A0A8C0M0C4, A0A8C0Q3M0, A0A8I3MZX9
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase
Nucleotide Protein
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