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UPF2 UPF2 regulator of nonsense mediated mRNA decay [ Canis lupus familiaris (dog) ]

Gene ID: 487130, updated on 25-Jul-2026
Official Symbol
UPF2provided by VGNC
Official Full Name
UPF2 regulator of nonsense mediated mRNA decayprovided by VGNC
Primary source
VGNC:VGNC:48151
See related
Ensembl:ENSCAFG00845000426 RGD:12373903
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See UPF2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (24741631..24844097)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (21395035..21497504)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (23426047..23528882)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (21868023..21970539)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (22711026..22813613)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit alpha 2 Neighboring gene proline-rich protein 2-like Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene U6 spliceosomal RNA Neighboring gene vegetative cell wall protein gp1-like Neighboring gene uncharacterized LOC111091559 Neighboring gene uncharacterized LOC119870153 Neighboring gene proline and serine rich 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of exon-exon junction complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
regulator of nonsense transcripts 2
Names
UPF2 regulator of nonsense transcripts homolog

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    24741631..24844097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038658441.1 → XP_038514369.1  regulator of nonsense transcripts 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JZQ0, A0A8I3MCN5
    Related
    ENSCAFP00845000486.1, ENSCAFT00845000676.1
    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

  2. XM_038658440.1 → XP_038514368.1  regulator of nonsense transcripts 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JZQ0, A0A8I3MCN5
    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

  3. XM_038658442.1 → XP_038514370.1  regulator of nonsense transcripts 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JZQ0
    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    21868023..21970539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038469380.1 → XP_038325308.1  

    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

  2. XM_038469379.1 → XP_038325307.1  

    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

  3. XM_038469381.1 → XP_038325309.1  

    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    22711026..22813613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038594384.1 → XP_038450312.1  

  2. XM_038594383.1 → XP_038450311.1  

  3. XM_038594385.1 → XP_038450313.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    23426047..23528882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038530131.1 → XP_038386059.1  regulator of nonsense transcripts 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JZQ0, A0A8I3MCN5
    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

  2. XM_038530130.1 → XP_038386058.1  regulator of nonsense transcripts 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JZQ0, A0A8I3MCN5
    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

  3. XM_038530132.1 → XP_038386060.1  regulator of nonsense transcripts 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JZQ0
    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21395035..21497504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022407842.2 → XP_022263550.1  regulator of nonsense transcripts 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JZQ0, A0A8I3MCN5
    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

  2. XM_022407840.2 → XP_022263548.1  regulator of nonsense transcripts 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JZQ0, A0A8I3MCN5
    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain

  3. XM_005617144.4 → XP_005617201.1  regulator of nonsense transcripts 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JZQ0
    Conserved Domains (4) summary
    smart00543
    Location:570 → 757
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:775 → 985
    MIF4G; MIF4G domain
    pfam04050
    Location:1094 → 1217
    Upf2; Up-frameshift suppressor 2
    cl19727
    Location:357 → 420
    DUF1451; Zinc-ribbon containing domain
Nucleotide Protein
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