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AFAP1L2 actin filament associated protein 1 like 2 [ Canis lupus familiaris (dog) ]

Gene ID: 486898, updated on 27-Jun-2026
Official Symbol
AFAP1L2provided by VGNC
Official Full Name
actin filament associated protein 1 like 2provided by VGNC
Primary source
VGNC:VGNC:49824
See related
Ensembl:ENSCAFG00845030675 RGD:12319458
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See AFAP1L2 in Genome Data Viewer
Location:
chromosome: 28
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 28 NC_051832.1 (25670683..25767385, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 28 NC_006610.4 (25288383..25385034, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 28 NC_049249.1 (25434826..25491955, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 28 NC_049288.1 (25226033..25322680, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 28 NC_049769.1 (25241116..25337719, complement)

Chromosome 28 - NC_051832.1Genomic Context describing neighboring genes Neighboring gene tudor domain containing 1 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene uncharacterized LOC111093074 Neighboring gene actin binding LIM protein 1 Neighboring gene uncharacterized LOC119866595 Neighboring gene FHF complex subunit HOOK interacting protein 2A

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH2 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-8 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
actin filament-associated protein 1-like 2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051832.1 Reference ROS_Cfam_1.0

    Range
    25670683..25767385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038440646.1 → XP_038296574.1  actin filament-associated protein 1-like 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3QAH8
    Related
    ENSCAFP00845042848.1, ENSCAFT00845054511.1
    Conserved Domains (3) summary
    cd13306
    Location:137 → 243
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:325 → 425
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:456 → 584
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  2. XM_038440645.1 → XP_038296573.1  actin filament-associated protein 1-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3QAH8
    Conserved Domains (3) summary
    cd13306
    Location:138 → 244
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:326 → 426
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:457 → 586
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  3. XM_038440651.1 → XP_038296579.1  actin filament-associated protein 1-like 2 isoform X10

    UniProtKB/TrEMBL
    A0A8I3Q7E4
    Conserved Domains (3) summary
    cd13306
    Location:109 → 215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297 → 397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:428 → 556
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  4. XM_038440650.1 → XP_038296578.1  actin filament-associated protein 1-like 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I3Q7E4
    Related
    ENSCAFP00845042856.1, ENSCAFT00845054521.1
    Conserved Domains (3) summary
    cd13306
    Location:109 → 215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297 → 397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:428 → 557
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  5. XM_038440652.1 → XP_038296580.1  actin filament-associated protein 1-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Related
    ENSCAFP00845042824.1, ENSCAFT00845054485.1
    Conserved Domains (3) summary
    cd13306
    Location:194 → 300
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:382 → 482
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:513 → 642
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  6. XM_038440649.1 → XP_038296577.1  actin filament-associated protein 1-like 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3Q4Y9
    Related
    ENSCAFP00845042835.1, ENSCAFT00845054497.1
    Conserved Domains (3) summary
    cd13306
    Location:212 → 318
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:400 → 500
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:531 → 660
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  7. XM_038440653.1 → XP_038296581.1  actin filament-associated protein 1-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    cd13306
    Location:138 → 244
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:326 → 426
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:457 → 586
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  8. XM_038440643.1 → XP_038296571.1  actin filament-associated protein 1-like 2 isoform X11

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    cd13306
    Location:137 → 243
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:325 → 425
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:456 → 585
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  9. XM_038440644.1 → XP_038296572.1  actin filament-associated protein 1-like 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    cd13306
    Location:137 → 243
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:325 → 425
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:456 → 584
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  10. XM_038440647.1 → XP_038296575.1  actin filament-associated protein 1-like 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    cd13306
    Location:109 → 215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297 → 397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:428 → 557
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  11. XM_038440648.1 → XP_038296576.1  actin filament-associated protein 1-like 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    cd13306
    Location:109 → 215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297 → 397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033913
    Location:428 → 556
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049288.1 Alternate UMICH_Zoey_3.1

    Range
    25226033..25322680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038515246.1 → XP_038371174.1  

  2. XM_038515245.1 → XP_038371173.1  

  3. XM_038515251.1 → XP_038371179.1  

  4. XM_038515250.1 → XP_038371178.1  

  5. XM_038515252.1 → XP_038371180.1  

  6. XM_038515249.1 → XP_038371177.1  

  7. XM_038515254.1 → XP_038371182.1  

  8. XM_038515253.1 → XP_038371181.1  

  9. XM_038515244.1 → XP_038371172.1  

  10. XM_038515243.1 → XP_038371171.1  

  11. XM_038515247.1 → XP_038371175.1  

    Conserved Domains (3) summary
    PHA03307
    Location:441 → 589
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13306
    Location:109 → 215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297 → 397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

  12. XM_038515248.1 → XP_038371176.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049769.1 Alternate UNSW_CanFamBas_1.0

    Range
    25241116..25337719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038643064.1 → XP_038498992.1  

  2. XM_038643063.1 → XP_038498991.1  

  3. XM_038643069.1 → XP_038498997.1  

  4. XM_038643068.1 → XP_038498996.1  

  5. XM_038643070.1 → XP_038498998.1  

  6. XM_038643067.1 → XP_038498995.1  

  7. XM_038643072.1 → XP_038499000.1  

  8. XM_038643071.1 → XP_038498999.1  

  9. XM_038643062.1 → XP_038498990.1  

  10. XM_038643061.1 → XP_038498989.1  

  11. XM_038643065.1 → XP_038498993.1  

    Conserved Domains (3) summary
    PHA03307
    Location:441 → 589
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13306
    Location:109 → 215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297 → 397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

  12. XM_038643066.1 → XP_038498994.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049249.1 Alternate UU_Cfam_GSD_1.0

    Range
    25434826..25491955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038578857.1 → XP_038434785.1  actin filament-associated protein 1-like 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3QAH8

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25288383..25385034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022412082.2 → XP_022267790.1  actin filament-associated protein 1-like 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3QAH8
    Conserved Domains (3) summary
    cd13306
    Location:137 → 243
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:325 → 425
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl28033
    Location:469 → 616
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  2. XM_038460342.1 → XP_038316270.1  actin filament-associated protein 1-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3QAH8
    Conserved Domains (3) summary
    PHA03307
    Location:470 → 618
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13306
    Location:138 → 244
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:326 → 426
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

  3. XM_022412087.2 → XP_022267795.1  actin filament-associated protein 1-like 2 isoform X10

    UniProtKB/TrEMBL
    A0A8C0KH38
    Conserved Domains (3) summary
    cd13306
    Location:109 → 215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297 → 397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl28033
    Location:441 → 588
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  4. XM_022412086.2 → XP_022267794.1  actin filament-associated protein 1-like 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I3Q7E4
    Conserved Domains (3) summary
    cd13306
    Location:109 → 215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297 → 397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl28033
    Location:441 → 589
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  5. XM_038460344.1 → XP_038316272.1  actin filament-associated protein 1-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    PHA03307
    Location:526 → 674
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13306
    Location:194 → 300
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:382 → 482
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

  6. XM_038460343.1 → XP_038316271.1  actin filament-associated protein 1-like 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3Q4Y9
    Conserved Domains (3) summary
    PHA03307
    Location:544 → 692
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13306
    Location:212 → 318
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:400 → 500
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

  7. XM_038460346.1 → XP_038316274.1  actin filament-associated protein 1-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    PHA03307
    Location:470 → 618
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13306
    Location:138 → 244
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:326 → 426
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

  8. XM_022412080.2 → XP_022267788.1  actin filament-associated protein 1-like 2 isoform X11

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    cd13306
    Location:137 → 243
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:325 → 425
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl28033
    Location:469 → 617
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  9. XM_022412081.2 → XP_022267789.1  actin filament-associated protein 1-like 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    cd13306
    Location:137 → 243
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:325 → 425
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl28033
    Location:469 → 616
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  10. XM_022412083.2 → XP_022267791.1  actin filament-associated protein 1-like 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    PHA03307
    Location:441 → 589
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13306
    Location:109 → 215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297 → 397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

  11. XM_022412084.2 → XP_022267792.1  actin filament-associated protein 1-like 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I3QAF5
    Conserved Domains (3) summary
    cd13306
    Location:109 → 215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297 → 397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl28033
    Location:441 → 588
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
Nucleotide Protein
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