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C1S complement C1s [ Canis lupus familiaris (dog) ]

Gene ID: 486714, updated on 27-Jun-2026
Official Symbol
C1Sprovided by VGNC
Official Full Name
complement C1sprovided by VGNC
Primary source
VGNC:VGNC:38588
See related
Ensembl:ENSCAFG00845025415 RGD:12084025
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See C1S in Genome Data Viewer
Location:
chromosome: 27
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (38328637..38338284, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (8630918..8640567)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (8109060..8118714)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (38203588..38213240, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (38244607..38254261, complement)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene complement C1r subcomponent like Neighboring gene complement C1r Neighboring gene lysophosphatidylcholine acyltransferase 3 Neighboring gene EMG1 N1-specific pseudouridine methyltransferase

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
complement C1s subcomponent
XP_005637267.1
XP_038295052.1
XP_038295053.1
XP_038369717.1
XP_038369718.1
XP_038432585.1
XP_038432586.1
XP_038497559.1
XP_038497560.1
XP_853320.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    38328637..38338284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038439125.1 → XP_038295053.1  complement C1s subcomponent

    UniProtKB/TrEMBL
    A0A8C0JQU2, A0A8I3PR28
    Related
    ENSCAFP00845035154.1, ENSCAFT00845044857.1
    Conserved Domains (5) summary
    cd00033
    Location:303 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_038439124.1 → XP_038295052.1  complement C1s subcomponent

    UniProtKB/TrEMBL
    A0A8C0JQU2, A0A8I3PR28
    Related
    ENSCAFP00845035317.1, ENSCAFT00845045055.1
    Conserved Domains (5) summary
    cd00033
    Location:303 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    38203588..38213240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038513790.1 → XP_038369718.1  

    Conserved Domains (5) summary
    cd00033
    Location:303 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_038513789.1 → XP_038369717.1  

    Conserved Domains (5) summary
    cd00033
    Location:303 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    38244607..38254261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038641632.1 → XP_038497560.1  

    Conserved Domains (5) summary
    cd00033
    Location:303 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_038641631.1 → XP_038497559.1  

    Conserved Domains (5) summary
    cd00033
    Location:303 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    8109060..8118714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038576657.1 → XP_038432585.1  complement C1s subcomponent

    UniProtKB/TrEMBL
    A0A8C0JQU2, A0A8I3PR28
    Conserved Domains (5) summary
    cd00033
    Location:303 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_038576658.1 → XP_038432586.1  complement C1s subcomponent

    UniProtKB/TrEMBL
    A0A8C0JQU2, A0A8I3PR28
    Conserved Domains (5) summary
    cd00033
    Location:303 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    8630918..8640567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_848227.6 → XP_853320.1  complement C1s subcomponent

    See identical proteins and their annotated locations for XP_853320.1

    UniProtKB/TrEMBL
    A0A8C0JQU2, A0A8I3PR28
    Conserved Domains (5) summary
    cd00033
    Location:303 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_005637210.4 → XP_005637267.1  complement C1s subcomponent

    See identical proteins and their annotated locations for XP_005637267.1

    UniProtKB/TrEMBL
    A0A8C0JQU2, A0A8I3PR28
    Conserved Domains (5) summary
    cd00033
    Location:303 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
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