DUSP16 dual specificity phosphatase 16 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: DUSP16provided by VGNC
Official Full Name: dual specificity phosphatase 16provided by VGNC
Primary source: VGNC:VGNC:40130
See related: Ensembl:ENSCAFG00845023953 RGD:12200513
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: all
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Genomic context

Location:: chromosome: 27

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	27	NC_051831.1 (34055803..34140045)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	27	NC_006609.4 (12612785..12734244, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	27	NC_049248.1 (12346927..12468377, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	27	NC_049287.1 (33948602..34032763)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	27	NC_049768.1 (33898280..33982495)

Chromosome 27 - NC_051831.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dual specificity protein phosphatase 16

XP_038294902.1

EC 3.1.3.16

EC 3.1.3.48

XP_038294903.1

EC 3.1.3.16

EC 3.1.3.48

XP_038315747.1

EC 3.1.3.16

EC 3.1.3.48

XP_038315748.1

EC 3.1.3.16

EC 3.1.3.48

XP_038315749.1

EC 3.1.3.16

EC 3.1.3.48

XP_038315750.1

EC 3.1.3.16

EC 3.1.3.48

XP_038315751.1

EC 3.1.3.16

EC 3.1.3.48

XP_038315752.1

EC 3.1.3.16

EC 3.1.3.48

XP_038315753.1

EC 3.1.3.16

EC 3.1.3.48

XP_038315754.1

EC 3.1.3.16

EC 3.1.3.48

XP_038315755.1

EC 3.1.3.16

EC 3.1.3.48

XP_038369565.1

EC 3.1.3.16

EC 3.1.3.48

XP_038369566.1

EC 3.1.3.16

EC 3.1.3.48

XP_038432752.1

EC 3.1.3.16

EC 3.1.3.48

XP_038432753.1

EC 3.1.3.16

EC 3.1.3.48

XP_038432754.1

EC 3.1.3.16

EC 3.1.3.48

XP_038432755.1

EC 3.1.3.16

EC 3.1.3.48

XP_038432756.1

EC 3.1.3.16

EC 3.1.3.48

XP_038432757.1

EC 3.1.3.16

EC 3.1.3.48

XP_038432758.1

EC 3.1.3.16

EC 3.1.3.48

XP_038432759.1

EC 3.1.3.16

EC 3.1.3.48

XP_038432760.1

EC 3.1.3.16

EC 3.1.3.48

XP_038432761.1

EC 3.1.3.16

EC 3.1.3.48

XP_038497382.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051831.1 Reference ROS_Cfam_1.0

Range

34055803..34140045

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038438974.1 → XP_038294902.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038438975.1 → XP_038294903.1 dual specificity protein phosphatase 16 isoform X2

UniProtKB/TrEMBL

A0A8C0K0N8, A0A8I3PQ41

Related

ENSCAFP00845033166.1, ENSCAFT00845042306.1

Conserved Domains (2) summary

cd01446
Location:10 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:157 → 301

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16

Alternate UMICH_Zoey_3.1

Genomic

NC_049287.1 Alternate UMICH_Zoey_3.1

Range

33948602..34032763

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038513637.1 → XP_038369565.1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038513638.1 → XP_038369566.1

Conserved Domains (2) summary

cd01446
Location:10 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:157 → 301

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049768.1 Alternate UNSW_CanFamBas_1.0

Range

33898280..33982495

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038641454.1 → XP_038497382.1

Conserved Domains (2) summary

cd01446
Location:10 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:157 → 301

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049248.1 Alternate UU_Cfam_GSD_1.0

Range

12346927..12468377 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038576827.1 → XP_038432755.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038576825.1 → XP_038432753.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038576831.1 → XP_038432759.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038576832.1 → XP_038432760.1 dual specificity protein phosphatase 16 isoform X2

UniProtKB/TrEMBL

A0A8C0K0N8, A0A8I3PQ41

Conserved Domains (2) summary

cd01446
Location:10 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:157 → 301

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038576824.1 → XP_038432752.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038576829.1 → XP_038432757.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038576828.1 → XP_038432756.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038576826.1 → XP_038432754.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038576830.1 → XP_038432758.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038576833.1 → XP_038432761.1 dual specificity protein phosphatase 16 isoform X3

Conserved Domains (1) summary

cd14646
Location:78 → 222

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

12612785..12734244 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038459821.1 → XP_038315749.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038459819.1 → XP_038315747.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038459825.1 → XP_038315753.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038459826.1 → XP_038315754.1 dual specificity protein phosphatase 16 isoform X2

UniProtKB/TrEMBL

A0A8C0K0N8, A0A8I3PQ41

Conserved Domains (2) summary

cd01446
Location:10 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:157 → 301

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038459823.1 → XP_038315751.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038459822.1 → XP_038315750.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038459820.1 → XP_038315748.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038459824.1 → XP_038315752.1 dual specificity protein phosphatase 16 isoform X1

Conserved Domains (2) summary

cd01446
Location:10 → 130

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14646
Location:210 → 354

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16
XM_038459827.1 → XP_038315755.1 dual specificity protein phosphatase 16 isoform X4

Conserved Domains (1) summary

cd14646
Location:78 → 222

DSP_DUSP16; dual specificity phosphatase domain of dual specificity protein phosphatase 16