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ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 [ Canis lupus familiaris (dog) ]

Gene ID: 486602, updated on 25-Jul-2026
Official Symbol
ADAMTS20provided by VGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 20provided by VGNC
Primary source
VGNC:VGNC:37599
See related
Ensembl:ENSCAFG00845029722 RGD:12133751
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ADAMTS20 in Genome Data Viewer
Location:
chromosome: 27
Exon count:
40
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (10688121..10851084)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (35646585..35809609, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (35895239..36058185, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (10499490..10662542)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (10532860..10695806)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase 7 like Neighboring gene uncharacterized LOC102156873 Neighboring gene uncharacterized LOC111092825 Neighboring gene serine/threonine-protein phosphatase 4 catalytic subunit-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. Wolf ZT, et al. PLoS Genet, 2015 Mar. PMID 25798845, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In summary, this study provides genetic evidence for a role of ADAMTS20 in CL/P development in dogs and as a candidate gene for CL/P development in humans.
    Title: Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 20

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    10688121..10851084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038438451.1 → XP_038294379.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X1

    UniProtKB/TrEMBL
    A0A8I3Q4T9
    Related
    ENSCAFP00845041711.1, ENSCAFT00845053118.1
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:725 → 843
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1718 → 1913
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1311 → 1362
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_038438454.1 → XP_038294382.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X4

    UniProtKB/TrEMBL
    A0A8I3Q4T9
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:725 → 843
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1659 → 1854
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1311 → 1362
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_038438453.1 → XP_038294381.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q4T9
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:725 → 843
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1682 → 1877
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1275 → 1326
    TSP1_ADAMTS; Thrombospondin type 1 domain

  4. XM_038438452.1 → XP_038294380.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X2

    UniProtKB/TrEMBL
    A0A8I3Q4T9
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:704 → 822
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1697 → 1892
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1290 → 1341
    TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    10499490..10662542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038513145.1 → XP_038369073.1  

  2. XM_038513148.1 → XP_038369076.1  

  3. XM_038513147.1 → XP_038369075.1  

  4. XM_038513146.1 → XP_038369074.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    10532860..10695806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038640915.1 → XP_038496843.1  

  2. XM_038640918.1 → XP_038496846.1  

  3. XM_038640917.1 → XP_038496845.1  

  4. XM_038640916.1 → XP_038496844.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    35895239..36058185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038577378.1 → XP_038433306.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KBY2
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:704 → 822
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1697 → 1892
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1290 → 1341
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_038577379.1 → XP_038433307.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KBY2
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:725 → 843
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1682 → 1877
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1275 → 1326
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_038577380.1 → XP_038433308.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KBY2
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:725 → 843
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1659 → 1854
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1311 → 1362
    TSP1_ADAMTS; Thrombospondin type 1 domain

  4. XM_038577377.1 → XP_038433305.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBY2
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:725 → 843
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1718 → 1913
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1311 → 1362
    TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    35646585..35809609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038459999.1 → XP_038315927.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KBY2
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:704 → 822
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1697 → 1892
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1290 → 1341
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_038460000.1 → XP_038315928.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KBY2
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:725 → 843
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1682 → 1877
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1275 → 1326
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_038460001.1 → XP_038315929.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KBY2
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:725 → 843
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1659 → 1854
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1311 → 1362
    TSP1_ADAMTS; Thrombospondin type 1 domain

  4. XM_847045.6 → XP_852138.4  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBY2
    Conserved Domains (7) summary
    smart00209
    Location:563 → 615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:262 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:725 → 843
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:41 → 186
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:1718 → 1913
    GON; GON domain
    pfam17771
    Location:483 → 550
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:1311 → 1362
    TSP1_ADAMTS; Thrombospondin type 1 domain
Nucleotide Protein
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