KRT71 keratin 71 [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: KRT71
Gene description: keratin 71
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human all
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Genomic context

Location:: chromosome: 27

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	27	NC_051831.1 (2535235..2543509)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	27	NC_006609.4 (43708920..43717192, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	27	NC_049248.1 (44107170..44115446, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	27	NC_049287.1 (2552838..2561108)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	27	NC_049768.1 (2538016..2546256)
105	previous assembly	CanFam3.1 (GCF_000002285.3)	27	NC_006609.3 (2536831..2545103)

Chromosome 27 - NC_051831.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel structural variant in exon 7 of the KRT71 gene predicted to result in a frameshift and stop loss, leading to a curly-haired phenotype.
Title: A novel KRT71 variant in curly-coated dogs.
The variant, NM_001197029.1:c.1266_1273delinsACA, was an indel variant in exon 7 that caused a frameshift and an altered and probably extended C-terminus of the KRT71 protein, causing a curly hair phenotype.
Title: A second KRT71 allele in curly coated dogs.
study identified distinct mutations in three genes, RSPO2, FGF5, and KRT71 (encoding R-spondin-2, fibroblast growth factor-5, and keratin-71, respectively), that together account for most coat phenotypes in purebred dogs in the United States
Title: Coat variation in the domestic dog is governed by variants in three genes.

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General gene information

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Homology

Homologs of the KRT71 gene: The KRT71 gene is conserved in human, chimpanzee, Rhesus monkey, cow, mouse, rat, and chicken.
Orthologs from Annotation Pipeline: 101 organisms have orthologs with human gene KRT71
Orthologs

General protein information

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Preferred Names: keratin, type II cytoskeletal 71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197029.1 → NP_001183958.1 keratin, type II cytoskeletal 71

See identical proteins and their annotated locations for NP_001183958.1

Status: PROVISIONAL

Source sequence(s)

FJ906970

UniProtKB/TrEMBL

D6BR72, E2R834

Conserved Domains (4) summary

pfam00038
Location:131 → 444

Filament; Intermediate filament protein

pfam16208
Location:16 → 128

Keratin_2_head; Keratin type II head

cl03075
Location:301 → 409

GrpE; nucleotide exchange factor GrpE

cl19885
Location:200 → 425

Sec6; Exocyst complex component Sec6