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AMHR2 anti-Mullerian hormone receptor type 2 [ Canis lupus familiaris (dog) ]

Gene ID: 486506, updated on 17-Aug-2024

Summary

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Official Symbol
AMHR2provided by VGNC
Official Full Name
anti-Mullerian hormone receptor type 2provided by VGNC
Primary source
VGNC:VGNC:37830
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 27
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (1791762..1796819, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (44455814..44462993)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (44856852..44864032)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (1809299..1816478, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (1793536..1800715, complement)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene poly(rC) binding protein 2 Neighboring gene proline rich 13 Neighboring gene Sp1 transcription factor Neighboring gene uncharacterized LOC111092798

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sertoli Cell Tumour and Uterine Leiomyoma in Miniature Schnauzer Dogs with Persistent Müllerian Duct Syndrome Caused by Mutation in the AMHR2 Gene. Dzimira S, et al. J Comp Pathol, 2018 May. PMID 30173854
  2. A single base pair mutation encoding a premature stop codon in the MIS type II receptor is responsible for canine persistent Müllerian duct syndrome. Wu X, et al. J Androl, 2009 Jan-Feb. PMID 18723470, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This report describes two miniature schnauzer dogs with persistent Mullerian duct syndrome caused by a known nonsense mutation in the AMHR2 gene, with concurrent development of genital neoplasia
    Title: Sertoli Cell Tumour and Uterine Leiomyoma in Miniature Schnauzer Dogs with Persistent Müllerian Duct Syndrome Caused by Mutation in the AMHR2 Gene.
  2. In the model of persistent Mullerian duct syndrome derived from the miniature schnauzer breed, a single base pair substitution introduces a stop codon in exon 3 of Mellerian inhibiting substance receptor.
    Title: A single base pair mutation encoding a premature stop codon in the MIS type II receptor is responsible for canine persistent Müllerian duct syndrome.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
anti-Muellerian hormone type-2 receptor; LOW QUALITY PROTEIN: anti-Muellerian hormone type-2 receptor
XP_038293864.1
XP_038368687.1
XP_038433716.1
XP_038496445.1
XP_543632.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    1791762..1796819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038437936.1 → XP_038293864.1  LOW QUALITY PROTEIN: anti-Muellerian hormone type-2 receptor isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:129 → 407
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    1809299..1816478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038512759.1 → XP_038368687.1  LOW QUALITY PROTEIN: anti-Muellerian hormone type-2 receptor isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    1793536..1800715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038640517.1 → XP_038496445.1  LOW QUALITY PROTEIN: anti-Muellerian hormone type-2 receptor isoform X3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    44856852..44864032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038577788.1 → XP_038433716.1  LOW QUALITY PROTEIN: anti-Muellerian hormone type-2 receptor isoform X4

    UniProtKB/TrEMBL
    A0A8C0PXV5

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    44455814..44462993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_543632.7 → XP_543632.4  LOW QUALITY PROTEIN: anti-Muellerian hormone type-2 receptor isoform X5

    UniProtKB/TrEMBL
    A0A8C0PXV5
    Conserved Domains (1) summary
    cl21453
    Location:221 → 522
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version