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MMP11 matrix metallopeptidase 11 [ Canis lupus familiaris (dog) ]

Gene ID: 486408, updated on 1-Mar-2025

Summary

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Official Symbol
MMP11provided by VGNC
Official Full Name
matrix metallopeptidase 11provided by VGNC
Primary source
VGNC:VGNC:43274
See related
Ensembl:ENSCAFG00845025865 RGD:12357662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See MMP11 in Genome Data Viewer
Location:
chromosome: 26
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (30135355..30147019, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (27804212..27813598, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (28823000..28832388, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (28217197..28226583, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (27835130..27844514, complement)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene derlin 3 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene chromosome 26 C22orf15 homolog Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene V-set pre-B cell surrogate light chain 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
stromelysin-3
Names
matrix metallopeptidase 11 (stromelysin 3)
matrix metalloproteinase 11
NP_001229661.1
XP_038292024.1
XP_038292025.1
XP_038292026.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242732.1 → NP_001229661.1  stromelysin-3 precursor

    Status: VALIDATED

    Source sequence(s)
    DN395318, HM163579, JAAUVH010000375
    UniProtKB/TrEMBL
    A0A8C0TA21, A0A8C0TCR5, A0A8I3PMD6, A0A8I3PMN6
    Related
    ENSCAFP00845035869.1, ENSCAFT00845045708.1
    Conserved Domains (2) summary
    cd00094
    Location:292 → 481
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:105 → 259
    Peptidase_M10; Matrixin

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    30135355..30147019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038436098.1 → XP_038292026.1  stromelysin-3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0TCR5, A0A8I3PMN6
    Related
    ENSCAFP00845035792.1, ENSCAFT00845045620.1
    Conserved Domains (2) summary
    cd00094
    Location:279 → 468
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:75 → 246
    Peptidase_M10; Matrixin

  2. XM_038436096.1 → XP_038292024.1  stromelysin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0TCR5, A0A8I3PMN6
    Conserved Domains (2) summary
    cd00094
    Location:309 → 498
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:105 → 276
    Peptidase_M10; Matrixin

  3. XM_038436097.1 → XP_038292025.1  stromelysin-3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TD76
    Conserved Domains (2) summary
    cd00094
    Location:285 → 474
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:81 → 252
    Peptidase_M10; Matrixin

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    28217197..28226583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    27835130..27844514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    28823000..28832388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    27804212..27813598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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