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SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 485864, updated on 4-Nov-2022

Summary

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Official Symbol
SRCprovided by VGNC
Official Full Name
SRC proto-oncogene, non-receptor tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:46791
See related
Ensembl:ENSCAFG00845028314
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SRC in Genome Data Viewer
Location:
chromosome: 24
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (26666859..26717079)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (25618275..25668243)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (26538700..26589113)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (25944146..25994080)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (26074538..26099748)
105 previous assembly CanFam3.1 (GCF_000002285.3) 24 NC_006606.3 (25982499..26019748)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111092065 Neighboring gene growth hormone releasing hormone Neighboring gene mannosidase beta like Neighboring gene uncharacterized LOC111092200 Neighboring gene uncharacterized LOC119865665 Neighboring gene uncharacterized LOC111092199 Neighboring gene uncharacterized LOC102155891

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Src triggers circular ruffling and macropinocytosis at the apical surface of polarized MDCK cells. Mettlen M, et al. Traffic, 2006 May. PMID 16643281
  2. Lysosomal targeting of E-cadherin: a unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitions. Palacios F, et al. Mol Cell Biol, 2005 Jan. PMID 15601859, Free PMC Article
  3. Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes. Medts T, et al. Exp Cell Res, 2010 Nov 15. PMID 20832399
  4. IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. Montaseri A, et al. PLoS One, 2011. PMID 22194879, Free PMC Article
  5. Role of Src signal transduction pathways in scatter factor-mediated cellular protection. Fan S, et al. J Biol Chem, 2009 Mar 20. PMID 19047046, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IGF-1 and PDGF-bb are potent inhibitors of IL-1beta-mediated activation of NF-kappaB and apoptosis in chondrocytes, may be mediated in part through suppression of Src/PI-3K/AKT pathway.
    Title: IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.
  2. Acute effects of Src in MDCK cells may mimic those of low EGF on EGFR activation and redistribution.
    Title: Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes.
  3. as a mediator of SF- and Src-stimulated NF-kappaB activity. Finally, the Src/Rac1/MKK3/6/p38 and Src/TAK1/NF-kappaB-inducing kinase pathways exhibited cross-talk at the level of MKK3.
    Title: Role of Src signal transduction pathways in scatter factor-mediated cellular protection.
  4. In polarized Madin-Darby canine kidney cells SRC promotes microtubule-dependent fusion of macropinosomes to the apical recycling endosome, causing its strong vacuolation.
    Title: Src triggers circular ruffling and macropinocytosis at the apical surface of polarized MDCK cells.
  5. the lysosomal targeting of E-cadherin is an important posttranscriptional mechanism to deplete cellular E-cadherin during Src-induced epithelial to mesenchymal transitions
    Title: Lysosomal targeting of E-cadherin: a unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitions.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

General protein information

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Preferred Names
LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src; proto-oncogene tyrosine-protein kinase Src
Names
src oncogene
tyrosine protein kinase pp60-c-src
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    26666859..26717079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038433789.1 → XP_038289717.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A8C0SX18, A0A8I3SBF9
    Related
    ENSCAFP00845039250.1, ENSCAFT00845050058.1
    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  2. XM_038433793.1 → XP_038289721.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    UniProtKB/TrEMBL
    A0A8C0PTA6, A0A8I3Q3E2
    Related
    ENSCAFP00845039211.1, ENSCAFT00845050010.1
    Conserved Domains (3) summary
    cd10365
    Location:153 → 253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266 → 542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  3. XM_038433794.1 → XP_038289722.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    UniProtKB/TrEMBL
    A0A8C0R008, A0A8C0Z0T7, A0A8I3Q3C2
    Related
    ENSCAFP00845039187.1, ENSCAFT00845049974.1
    Conserved Domains (3) summary
    cd10365
    Location:147 → 247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260 → 536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  4. XM_038433792.1 → XP_038289720.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A8C0SX18, A0A8I3SBF9
    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  5. XM_038433790.1 → XP_038289718.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A8C0SX18, A0A8I3SBF9
    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  6. XM_038433791.1 → XP_038289719.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A8C0SX18, A0A8I3SBF9
    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    25944146..25994080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038508938.1 → XP_038364866.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  2. XM_038508942.1 → XP_038364870.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    Conserved Domains (3) summary
    cd10365
    Location:153 → 253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266 → 542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  3. XM_038508943.1 → XP_038364871.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    Conserved Domains (3) summary
    cd10365
    Location:147 → 247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260 → 536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  4. XM_038508941.1 → XP_038364869.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  5. XM_038508939.1 → XP_038364867.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  6. XM_038508940.1 → XP_038364868.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    26074538..26099748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038636529.1 → XP_038492457.1  LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src isoform X3

    Conserved Domains (3) summary
    cd10365
    Location:153 → 253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266 → 542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    26538700..26589113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038572270.1 → XP_038428198.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  2. XM_038572274.1 → XP_038428202.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    Conserved Domains (3) summary
    cd10365
    Location:153 → 253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266 → 542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  3. XM_038572275.1 → XP_038428203.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    Conserved Domains (3) summary
    cd10365
    Location:147 → 247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260 → 536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  4. XM_038572273.1 → XP_038428201.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  5. XM_038572271.1 → XP_038428199.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  6. XM_038572272.1 → XP_038428200.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25618275..25668243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038457722.1 → XP_038313650.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A8C0SX18, A0A8I3SBF9
    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  2. XM_038457725.1 → XP_038313653.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    UniProtKB/TrEMBL
    A0A8C0PTA6, A0A8I3Q3E2
    Conserved Domains (3) summary
    cd10365
    Location:153 → 253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266 → 542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  3. XM_038457726.1 → XP_038313654.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    UniProtKB/TrEMBL
    A0A8C0R008, A0A8C0Z0T7, A0A8I3Q3C2
    Conserved Domains (3) summary
    cd10365
    Location:147 → 247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260 → 536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  4. XM_038457724.1 → XP_038313652.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A8C0SX18, A0A8I3SBF9
    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  5. XM_005635037.4 → XP_005635094.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_005635094.1

    UniProtKB/TrEMBL
    A0A8C0SX18, A0A8I3SBF9
    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  6. XM_038457723.1 → XP_038313651.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A8C0SX18, A0A8I3SBF9
    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
Nucleotide Protein
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