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NKX2-2 NK2 homeobox 2 [ Canis lupus familiaris (dog) ]

Gene ID: 485744, updated on 27-Jun-2026
Official Symbol
NKX2-2provided by VGNC
Official Full Name
NK2 homeobox 2provided by VGNC
Primary source
VGNC:VGNC:43833
See related
Ensembl:ENSCAFG00845027437 RGD:12188523
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See NKX2-2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
3
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (2337619..2340304)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (1958452..1961136)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (2314779..2317463)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (1934805..1937487)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (2037841..2040531)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene paired box 1 Neighboring gene gametogenetin-like Neighboring gene uncharacterized LOC111092249 Neighboring gene uncharacterized LOC111092209

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
homeobox protein Nkx-2.2
Names
NK2 transcription factor related, locus 2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    2337619..2340304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432954.1 → XP_038288882.1  homeobox protein Nkx-2.2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R938, A0A8I3SAT7
    Related
    ENSCAFP00845037921.1, ENSCAFT00845048335.1
    Conserved Domains (1) summary
    pfam00046
    Location:131 → 185
    Homeobox; Homeobox domain

  2. XM_038432955.1 → XP_038288883.1  homeobox protein Nkx-2.2 isoform X2

    Conserved Domains (1) summary
    pfam00046
    Location:90 → 144
    Homeobox; Homeobox domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    1934805..1937487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038508167.1 → XP_038364095.1  

    Conserved Domains (1) summary
    pfam00046
    Location:131 → 185
    Homeobox; Homeobox domain

  2. XM_038508168.1 → XP_038364096.1  

    Conserved Domains (1) summary
    pfam00046
    Location:90 → 144
    Homeobox; Homeobox domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    2037841..2040531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038635657.1 → XP_038491585.1  

    Conserved Domains (1) summary
    pfam00046
    Location:131 → 185
    Homeobox; Homeobox domain

  2. XM_038635658.1 → XP_038491586.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    2314779..2317463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038571422.1 → XP_038427350.1  homeobox protein Nkx-2.2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R938, A0A8I3SAT7
    Conserved Domains (1) summary
    pfam00046
    Location:131 → 185
    Homeobox; Homeobox domain

  2. XM_038571423.1 → XP_038427351.1  homeobox protein Nkx-2.2 isoform X2

    Conserved Domains (1) summary
    pfam00046
    Location:90 → 144
    Homeobox; Homeobox domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    1958452..1961136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_542867.7 → XP_542867.2  homeobox protein Nkx-2.2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R938, A0A8I3SAT7
    Conserved Domains (1) summary
    pfam00046
    Location:131 → 185
    Homeobox; Homeobox domain

  2. XM_014107317.3 → XP_013962792.1  homeobox protein Nkx-2.2 isoform X2

    Conserved Domains (1) summary
    pfam00046
    Location:90 → 144
    Homeobox; Homeobox domain
Nucleotide Protein
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