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RASA2 RAS p21 protein activator 2 [ Canis lupus familiaris (dog) ]

Gene ID: 485692, updated on 25-Jul-2026
Official Symbol
RASA2provided by VGNC
Official Full Name
RAS p21 protein activator 2provided by VGNC
Primary source
VGNC:VGNC:45360
See related
Ensembl:ENSCAFG00845028112 RGD:12432864
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See RASA2 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
31
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (37886431..38039822)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (37348977..37501906)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (37889916..38043155)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (37569880..37722763)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (37647104..37800458)

Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene 2-phosphoxylose phosphatase 1 Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene uncharacterized LOC119865404 Neighboring gene leucine rich repeat containing 78 Neighboring gene ring finger protein 7 Neighboring gene G protein-coupled receptor kinase 7

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
ras GTPase-activating protein 2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051827.1 Reference ROS_Cfam_1.0

    Range
    37886431..38039822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432541.1 → XP_038288469.1  ras GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K630
    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  2. XM_038432542.1 → XP_038288470.1  ras GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K630
    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  3. XM_038432543.1 → XP_038288471.1  ras GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K630
    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  4. XM_038432539.1 → XP_038288467.1  ras GTPase-activating protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PVQ4
    Conserved Domains (5) summary
    smart00107
    Location:708 → 743
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:172 → 314
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:39 → 159
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:323 → 593
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:590 → 723
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain

  5. XM_038432540.1 → XP_038288468.1  ras GTPase-activating protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PVQ4
    Related
    ENSCAFP00845038936.1, ENSCAFT00845049639.1
    Conserved Domains (5) summary
    smart00107
    Location:707 → 742
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:172 → 314
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:39 → 159
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:323 → 593
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:590 → 722
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049283.1 Alternate UMICH_Zoey_3.1

    Range
    37569880..37722763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038507844.1 → XP_038363772.1  

    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  2. XM_038507845.1 → XP_038363773.1  

    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  3. XM_038507846.1 → XP_038363774.1  

    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  4. XM_038507842.1 → XP_038363770.1  

    Conserved Domains (5) summary
    smart00107
    Location:708 → 743
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:172 → 314
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:39 → 159
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:323 → 593
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:590 → 723
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain

  5. XM_038507843.1 → XP_038363771.1  

    Conserved Domains (5) summary
    smart00107
    Location:707 → 742
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:172 → 314
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:39 → 159
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:323 → 593
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:590 → 722
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

    Range
    37647104..37800458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038635277.1 → XP_038491205.1  

    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  2. XM_038635278.1 → XP_038491206.1  

    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  3. XM_038635279.1 → XP_038491207.1  

    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  4. XM_038635275.1 → XP_038491203.1  

    Conserved Domains (5) summary
    smart00107
    Location:708 → 743
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:172 → 314
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:39 → 159
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:323 → 593
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:590 → 723
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain

  5. XM_038635276.1 → XP_038491204.1  

    Conserved Domains (5) summary
    smart00107
    Location:707 → 742
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:172 → 314
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:39 → 159
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:323 → 593
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:590 → 722
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

    Range
    37889916..38043155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038571086.1 → XP_038427014.1  ras GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K630
    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  2. XM_038571087.1 → XP_038427015.1  ras GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K630
    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  3. XM_038571088.1 → XP_038427016.1  ras GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K630
    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  4. XM_038571084.1 → XP_038427012.1  ras GTPase-activating protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PVQ4
    Conserved Domains (5) summary
    smart00107
    Location:708 → 743
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:172 → 314
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:39 → 159
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:323 → 593
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:590 → 723
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain

  5. XM_038571085.1 → XP_038427013.1  ras GTPase-activating protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PVQ4
    Conserved Domains (5) summary
    smart00107
    Location:707 → 742
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:172 → 314
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:39 → 159
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:323 → 593
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:590 → 722
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37348977..37501906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038457065.1 → XP_038312993.1  ras GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K630
    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  2. XM_038457066.1 → XP_038312994.1  ras GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K630
    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  3. XM_038457067.1 → XP_038312995.1  ras GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K630
    Conserved Domains (5) summary
    smart00107
    Location:650 → 685
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 665
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  4. XM_038457063.1 → XP_038312991.1  ras GTPase-activating protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PVQ4
    Conserved Domains (5) summary
    smart00107
    Location:708 → 743
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:172 → 314
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:39 → 159
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:323 → 593
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:590 → 723
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain

  5. XM_038457064.1 → XP_038312992.1  ras GTPase-activating protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PVQ4
    Conserved Domains (5) summary
    smart00107
    Location:707 → 742
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:172 → 314
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:39 → 159
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:323 → 593
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:590 → 722
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
Nucleotide Protein
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