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MCF2L MCF.2 cell line derived transforming sequence like [ Canis lupus familiaris (dog) ]

Gene ID: 485555, updated on 25-Jul-2026
Official Symbol
MCF2Lprovided by VGNC
Official Full Name
MCF.2 cell line derived transforming sequence likeprovided by VGNC
Primary source
VGNC:VGNC:43074
See related
RGD:12417014
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See MCF2L in Genome Data Viewer
Location:
chromosome: 22
Exon count:
29
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 22 NC_051826.1 (61067610..61196177)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 22 NC_006604.4 (60154082..60283316)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 22 NC_049243.1 (60598080..60727816)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 22 NC_049282.1 (60565665..60694793)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 22 NC_049763.1 (60563111..60696961)

Chromosome 22 - NC_051826.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119865242 Neighboring gene ATPase phospholipid transporting 11A Neighboring gene U4 spliceosomal RNA Neighboring gene coagulation factor VII Neighboring gene coagulation factor X

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Analysis of the partial nucleotide sequences and deduced primary structures of the protease domains of mammalian blood coagulation factors VII and X. Murakawa M, et al. Eur J Haematol, 1994 Mar. PMID 8168596
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extrinsic component of membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
guanine nucleotide exchange factor DBS
Names
coagulation factor VII

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051826.1 Reference ROS_Cfam_1.0

    Range
    61067610..61196177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038430792.1 → XP_038286720.1  guanine nucleotide exchange factor DBS isoform X1

    UniProtKB/TrEMBL
    A0A8I3PZ37
    Conserved Domains (4) summary
    cd11857
    Location:935 → 989
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:476 → 629
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01227
    Location:636 → 767
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049282.1 Alternate UMICH_Zoey_3.1

    Range
    60565665..60694793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038506876.1 → XP_038362804.1  

  2. XM_038506879.1 → XP_038362807.1  

    Conserved Domains (5) summary
    cd11857
    Location:1115 → 1169
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  3. XM_038506883.1 → XP_038362811.1  

    Conserved Domains (5) summary
    cd11857
    Location:1059 → 1113
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 560
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  4. XM_038506881.1 → XP_038362809.1  

    Conserved Domains (5) summary
    cd11857
    Location:1084 → 1138
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  5. XM_038506880.1 → XP_038362808.1  

  6. XM_038506885.1 → XP_038362813.1  

  7. XM_038506884.1 → XP_038362812.1  

  8. XM_038506877.1 → XP_038362805.1  

  9. XM_038506878.1 → XP_038362806.1  

  10. XM_038506882.1 → XP_038362810.1  

  11. XM_038506886.1 → XP_038362814.1  

    Conserved Domains (5) summary
    cd11857
    Location:1008 → 1062
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:23 → 114
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:525 → 702
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:247 → 453
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:709 → 840
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049763.1 Alternate UNSW_CanFamBas_1.0

    Range
    60563111..60696961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038634257.1 → XP_038490185.1  

  2. XM_038634260.1 → XP_038490188.1  

    Conserved Domains (5) summary
    cd11857
    Location:1115 → 1169
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  3. XM_038634265.1 → XP_038490193.1  

    Conserved Domains (5) summary
    cd11857
    Location:1059 → 1113
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 560
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  4. XM_038634263.1 → XP_038490191.1  

    Conserved Domains (5) summary
    cd11857
    Location:1084 → 1138
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  5. XM_038634261.1 → XP_038490189.1  

  6. XM_038634268.1 → XP_038490196.1  

  7. XM_038634266.1 → XP_038490194.1  

  8. XM_038634258.1 → XP_038490186.1  

  9. XM_038634259.1 → XP_038490187.1  

  10. XM_038634264.1 → XP_038490192.1  

  11. XM_038634267.1 → XP_038490195.1  

    Conserved Domains (5) summary
    cd11857
    Location:1008 → 1062
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:23 → 114
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:525 → 702
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:247 → 453
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:709 → 840
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049243.1 Alternate UU_Cfam_GSD_1.0

    Range
    60598080..60727816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038570088.1 → XP_038426016.1  guanine nucleotide exchange factor DBS isoform X24

    UniProtKB/TrEMBL
    A0A8C0L7X7

  2. XM_038570091.1 → XP_038426019.1  guanine nucleotide exchange factor DBS isoform X27

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1115 → 1169
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  3. XM_038570096.1 → XP_038426024.1  guanine nucleotide exchange factor DBS isoform X31

    UniProtKB/TrEMBL
    A0A8C0L5C6
    Conserved Domains (5) summary
    cd11857
    Location:1059 → 1113
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 560
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  4. XM_038570094.1 → XP_038426022.1  guanine nucleotide exchange factor DBS isoform X29

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1084 → 1138
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  5. XM_038570092.1 → XP_038426020.1  guanine nucleotide exchange factor DBS isoform X28

    UniProtKB/TrEMBL
    A0A8C0L7X7

  6. XM_038570099.1 → XP_038426027.1  guanine nucleotide exchange factor DBS isoform X34

    UniProtKB/TrEMBL
    A0A8C0L5C6

  7. XM_038570097.1 → XP_038426025.1  guanine nucleotide exchange factor DBS isoform X32

    UniProtKB/TrEMBL
    A0A8C0L7X7

  8. XM_038570089.1 → XP_038426017.1  guanine nucleotide exchange factor DBS isoform X25

    UniProtKB/TrEMBL
    A0A8C0R491

  9. XM_038570090.1 → XP_038426018.1  guanine nucleotide exchange factor DBS isoform X26

    UniProtKB/TrEMBL
    A0A8C0L7X7

  10. XM_038570095.1 → XP_038426023.1  guanine nucleotide exchange factor DBS isoform X30

    UniProtKB/TrEMBL
    A0A8C0L7X7

  11. XM_038570098.1 → XP_038426026.1  guanine nucleotide exchange factor DBS isoform X33

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1008 → 1062
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:23 → 114
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:525 → 702
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:247 → 453
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:709 → 840
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006604.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    60154082..60283316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014106461.3 → XP_013961936.1  guanine nucleotide exchange factor DBS isoform X35

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1115 → 1169
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  2. XM_038456694.1 → XP_038312622.1  guanine nucleotide exchange factor DBS isoform X38

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1115 → 1169
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  3. XM_038456696.1 → XP_038312624.1  guanine nucleotide exchange factor DBS isoform X42

    UniProtKB/TrEMBL
    A0A8C0L5C6
    Conserved Domains (5) summary
    cd11857
    Location:1059 → 1113
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 560
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  4. XM_038456695.1 → XP_038312623.1  guanine nucleotide exchange factor DBS isoform X40

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1084 → 1138
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:354 → 554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  5. XM_005634116.4 → XP_005634173.1  guanine nucleotide exchange factor DBS isoform X39

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1085 → 1139
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46 → 191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:602 → 779
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:324 → 530
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:786 → 917
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  6. XM_014106465.3 → XP_013961940.1  guanine nucleotide exchange factor DBS isoform X45

    UniProtKB/TrEMBL
    A0A8C0L5C6
    Conserved Domains (5) summary
    cd11857
    Location:1029 → 1083
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46 → 191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:602 → 779
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:324 → 530
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:786 → 917
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  7. XM_005634120.3 → XP_005634177.1  guanine nucleotide exchange factor DBS isoform X43

    See identical proteins and their annotated locations for XP_005634177.1

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1056 → 1110
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17 → 162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:573 → 750
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:295 → 501
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:757 → 888
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  8. XM_005634114.4 → XP_005634171.1  guanine nucleotide exchange factor DBS isoform X36

    UniProtKB/TrEMBL
    A0A8C0R491
    Conserved Domains (5) summary
    cd11857
    Location:1093 → 1147
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:54 → 199
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:610 → 787
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:332 → 538
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:794 → 925
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  9. XM_005634115.4 → XP_005634172.1  guanine nucleotide exchange factor DBS isoform X37

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1091 → 1145
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:52 → 197
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:608 → 785
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:330 → 536
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:792 → 923
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  10. XM_005634117.4 → XP_005634174.1  guanine nucleotide exchange factor DBS isoform X41

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1083 → 1137
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44 → 189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600 → 777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322 → 528
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784 → 915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  11. XM_005634122.4 → XP_005634179.2  guanine nucleotide exchange factor DBS isoform X44

    UniProtKB/TrEMBL
    A0A8C0L7X7
    Conserved Domains (5) summary
    cd11857
    Location:1008 → 1062
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:23 → 114
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:525 → 702
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:247 → 453
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:709 → 840
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
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