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SMPD1 sphingomyelin phosphodiesterase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 485334, updated on 27-Jun-2026
Official Symbol
SMPD1provided by VGNC
Official Full Name
sphingomyelin phosphodiesterase 1provided by VGNC
Primary source
VGNC:VGNC:46569
See related
Ensembl:ENSCAFG00845007383 RGD:12166714
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SMPD1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (30540703..30545329)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (29416446..29421072)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (30222733..30227359)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (29861608..29866232)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (30027386..30032012)

Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111091542 Neighboring gene caveolae associated protein 3 Neighboring gene uncharacterized LOC111091543 Neighboring gene amyloid beta precursor protein binding family B member 1 Neighboring gene uncharacterized LOC102156231

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Clostridium perfringens epsilon-toxin requires acid sphingomyelinase for cellular entry. Sakaguchi Y, et al. Anaerobe, 2023 Aug. PMID 37308057
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clostridium perfringens epsilon-toxin requires acid sphingomyelinase for cellular entry.
    Title: Clostridium perfringens epsilon-toxin requires acid sphingomyelinase for cellular entry.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables acid sphingomyelin phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sphingomyelin catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
sphingomyelin phosphodiesterase
Names
acid sphingomyelinase
XP_038286290.1
XP_038361620.1
XP_038424825.1
XP_038488991.1
XP_542452.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051825.1 Reference ROS_Cfam_1.0

    Range
    30540703..30545329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038430362.1 → XP_038286290.1  sphingomyelin phosphodiesterase

    UniProtKB/TrEMBL
    A0A8C0K937, A0A8I3RTW7
    Related
    ENSCAFP00845010161.1, ENSCAFT00845013044.1
    Conserved Domains (2) summary
    smart00741
    Location:81 → 154
    SapB; Saposin (B) Domains
    cd00842
    Location:195 → 490
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049281.1 Alternate UMICH_Zoey_3.1

    Range
    29861608..29866232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038505692.1 → XP_038361620.1  

    Conserved Domains (2) summary
    smart00741
    Location:81 → 154
    SapB; Saposin (B) Domains
    cd00842
    Location:195 → 490
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

    Range
    30027386..30032012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038633063.1 → XP_038488991.1  

    Conserved Domains (2) summary
    smart00741
    Location:81 → 154
    SapB; Saposin (B) Domains
    cd00842
    Location:195 → 490
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

    Range
    30222733..30227359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038568897.1 → XP_038424825.1  sphingomyelin phosphodiesterase

    UniProtKB/TrEMBL
    A0A8C0K937, A0A8I3RTW7
    Conserved Domains (2) summary
    smart00741
    Location:81 → 154
    SapB; Saposin (B) Domains
    cd00842
    Location:195 → 490
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    29416446..29421072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_542452.6 → XP_542452.1  sphingomyelin phosphodiesterase

    UniProtKB/TrEMBL
    A0A8C0K937, A0A8I3RTW7
    Conserved Domains (2) summary
    smart00741
    Location:81 → 154
    SapB; Saposin (B) Domains
    cd00842
    Location:195 → 490
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version

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