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ADGRE1 adhesion G protein-coupled receptor E1 [ Canis lupus familiaris (dog) ]

Gene ID: 485015, updated on 25-Jul-2026
Official Symbol
ADGRE1provided by VGNC
Official Full Name
adhesion G protein-coupled receptor E1provided by VGNC
Primary source
VGNC:VGNC:37636
See related
Ensembl:ENSCAFG00845007962 RGD:12276233
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
EMR1
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ADGRE1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
28
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (54058184..54120272, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (53154280..53214040, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (53803931..53864739, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (53126876..53187421, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (53574601..53635395, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene putative adhesion G protein-coupled receptor E4P Neighboring gene EGF-like module containing, mucin-like, hormone receptor-like sequence 4 Neighboring gene vav guanine nucleotide exchange factor 1 Neighboring gene SH2 domain containing 3A Neighboring gene thyroid hormone receptor interactor 10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. Kwakkenbos MJ, et al. FASEB J, 2006 Dec. PMID 17068111
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
adhesion G protein-coupled receptor E1
Names
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
egf-like module containing, mucin-like, hormone receptor-like 1
NP_001033757.1

Length

  • 1162

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038668.1 → NP_001033757.1  adhesion G protein-coupled receptor E1 precursor

    See identical proteins and their annotated locations for NP_001033757.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ227275
    UniProtKB/TrEMBL
    A0A8I3RVU2, Q2Q422
    Related
    ENSCAFP00845011002.1, ENSCAFT00845014189.1
    Conserved Domains (5) summary
    smart00179
    Location:508 → 547
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:29 → 60
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00002
    Location:875 → 1116
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:824 → 866
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:311 → 343
    EGF_CA; Calcium-binding EGF domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    54058184..54120272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038426486.1 → XP_038282414.1  adhesion G protein-coupled receptor E1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3N3Y1
    Conserved Domains (5) summary
    smart00303
    Location:730 → 776
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:416 → 455
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:29 → 60
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:219 → 251
    EGF_CA; Calcium-binding EGF domain
    cd15439
    Location:783 → 1045
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

  2. XM_038426485.1 → XP_038282413.1  adhesion G protein-coupled receptor E1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3RVU2
    Conserved Domains (5) summary
    smart00303
    Location:757 → 803
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:443 → 482
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:342 → 373
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:246 → 278
    EGF_CA; Calcium-binding EGF domain
    cd15439
    Location:810 → 1072
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    53126876..53187421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    53574601..53635395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    53803931..53864739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    53154280..53214040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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