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CNOT4 CCR4-NOT transcription complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 4850, updated on 7-Jun-2020

Summary

Official Symbol
CNOT4provided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:7880
See related
Ensembl:ENSG00000080802 MIM:604911
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOT4; NOT4H; CLONE243
Summary
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in testis (RPKM 8.1), brain (RPKM 5.5) and 25 other tissues See more
Orthologs

Genomic context

See CNOT4 in Genome Data Viewer
Location:
7q33
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (135361795..135510127, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (135046547..135194875, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984123 Neighboring gene stimulated by retinoic acid 8 Neighboring gene solute carrier family 23 member 4, pseudogene Neighboring gene succinate dehydrogenase complex subunit D pseudogene 2 Neighboring gene nucleoporin 205 Neighboring gene MAX pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 4
Names
CCR4-associated factor 4
E3 ubiquitin-protein ligase CNOT4
NOT4 (negative regulator of transcription 4, yeast) homolog
RING-type E3 ubiquitin transferase CNOT4
potential transcriptional repressor NOT4Hp
NP_001008226.1
NP_001177776.1
NP_001177777.1
NP_001177778.1
NP_001177779.1
NP_037448.2
XP_016867724.1
XP_024302540.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008225.2NP_001008226.1  CCR4-NOT transcription complex subunit 4 isoform b

    See identical proteins and their annotated locations for NP_001008226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon and differs in the 3' UTR and coding sequence compared to variant 6. The resulting isoform (b) lacks an internal 3 aa segment and has a shorter and distinct C-terminus compared to isoform f.
    Source sequence(s)
    AC009331, AC083871, AL389980, DA247976
    Consensus CDS
    CCDS47719.1
    UniProtKB/Swiss-Prot
    O95628
    UniProtKB/TrEMBL
    A0A024R776
    Related
    ENSP00000399108.2, ENST00000428680.6
    Conserved Domains (1) summary
    COG5175
    Location:14319
    MOT2; Transcriptional repressor [Transcription]
  2. NM_001190847.2NP_001177776.1  CCR4-NOT transcription complex subunit 4 isoform c

    See identical proteins and their annotated locations for NP_001177776.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 6. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform f.
    Source sequence(s)
    AC009331, AC083871, AK314540, DA247976, U71267
    Consensus CDS
    CCDS55164.1
    UniProtKB/Swiss-Prot
    O95628
    UniProtKB/TrEMBL
    A0A024R781
    Related
    ENSP00000406777.2, ENST00000423368.6
    Conserved Domains (1) summary
    COG5175
    Location:14322
    MOT2; Transcriptional repressor [Transcription]
  3. NM_001190848.1NP_001177777.1  CCR4-NOT transcription complex subunit 4 isoform d

    See identical proteins and their annotated locations for NP_001177777.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 6. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform f.
    Source sequence(s)
    AC009331, AC083871, AL389980, DA247976, U71268
    Consensus CDS
    CCDS55166.1
    UniProtKB/Swiss-Prot
    O95628
    UniProtKB/TrEMBL
    A0A024R785
    Related
    ENSP00000326731.5, ENST00000315544.6
    Conserved Domains (1) summary
    COG5175
    Location:14322
    MOT2; Transcriptional repressor [Transcription]
  4. NM_001190849.2NP_001177778.1  CCR4-NOT transcription complex subunit 4 isoform e

    See identical proteins and their annotated locations for NP_001177778.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. The resulting isoform (e) has the same N- and C-termini but is 3 aa shorter compared to isoform f.
    Source sequence(s)
    AC009331, AC083871, AK314540, CA396599, DA247976
    Consensus CDS
    CCDS55167.1
    UniProtKB/Swiss-Prot
    O95628
    Related
    ENSP00000388491.1, ENST00000451834.5
    Conserved Domains (1) summary
    COG5175
    Location:14319
    MOT2; Transcriptional repressor [Transcription]
  5. NM_001190850.1NP_001177779.1  CCR4-NOT transcription complex subunit 4 isoform f

    See identical proteins and their annotated locations for NP_001177779.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (f).
    Source sequence(s)
    AC009331, AC083871, AK314540, CA396599, DA247976, U71267
    Consensus CDS
    CCDS55165.1
    UniProtKB/Swiss-Prot
    O95628
    Related
    ENSP00000445508.1, ENST00000541284.5
    Conserved Domains (1) summary
    COG5175
    Location:14322
    MOT2; Transcriptional repressor [Transcription]
  6. NM_013316.4NP_037448.2  CCR4-NOT transcription complex subunit 4 isoform a

    See identical proteins and their annotated locations for NP_037448.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 3' end of an exon and lacks an alternate in-frame exon compared to variant 6. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform f.
    Source sequence(s)
    AC009331, AC083871, AK314540, DA247976
    Consensus CDS
    CCDS43650.1
    UniProtKB/Swiss-Prot
    O95628
    Related
    ENSP00000354673.4, ENST00000361528.8
    Conserved Domains (1) summary
    COG5175
    Location:14319
    MOT2; Transcriptional repressor [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    135361795..135510127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012235.1XP_016867724.1  CCR4-NOT transcription complex subunit 4 isoform X1

    UniProtKB/Swiss-Prot
    O95628
    Conserved Domains (1) summary
    COG5175
    Location:14322
    MOT2; Transcriptional repressor [Transcription]
  2. XM_024446772.1XP_024302540.1  CCR4-NOT transcription complex subunit 4 isoform X2

    Conserved Domains (1) summary
    COG5175
    Location:14319
    MOT2; Transcriptional repressor [Transcription]
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