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INSR insulin receptor [ Canis lupus familiaris (dog) ]

Gene ID: 484990, updated on 25-Jul-2026
Official Symbol
INSRprovided by VGNC
Official Full Name
insulin receptorprovided by VGNC
Primary source
VGNC:VGNC:42043
See related
Ensembl:ENSCAFG00845024484 RGD:12377291
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See INSR in Genome Data Viewer
Location:
chromosome: 20
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (52547342..52682557, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (51822227..51957301, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (52425027..52560283, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (51751620..51886677, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (52194853..52330054, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 558-like Neighboring gene vomeronasal 2 receptor 306 pseudogene Neighboring gene uncharacterized LOC119864756 Neighboring gene uncharacterized LOC119864753

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
insulin receptor
XP_022262798.2
XP_038284657.1
XP_038284659.1
XP_038284660.1
XP_038284661.1
XP_038311085.1
XP_038311086.1
XP_038311087.1
XP_038360900.1

Length

  • 1381
XP_038423334.1
XP_038423335.1
XP_038423336.1
XP_038423337.1
XP_038487484.1
XP_038487485.1
XP_038487486.1
XP_038487487.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    52547342..52682557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038428731.1 → XP_038284659.1  insulin receptor isoform X2

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Related
    ENSCAFP00845034063.1, ENSCAFT00845043478.1
    Conserved Domains (5) summary
    cd05061
    Location:966 → 1253
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:817 → 894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:142 → 300
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:322 → 435
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:890 → 937
    Insulin_TMD; Insulin receptor trans-membrane segment

  2. XM_038428729.1 → XP_038284657.1  insulin receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Related
    ENSCAFP00845033901.1, ENSCAFT00845043247.1
    Conserved Domains (5) summary
    cd05061
    Location:978 → 1265
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:829 → 906
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:142 → 300
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:322 → 435
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:902 → 949
    Insulin_TMD; Insulin receptor trans-membrane segment

  3. XM_038428733.1 → XP_038284661.1  insulin receptor isoform X4

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Conserved Domains (5) summary
    cd05061
    Location:805 → 1092
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:656 → 733
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:8 → 127
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:149 → 262
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:729 → 776
    Insulin_TMD; Insulin receptor trans-membrane segment

  4. XM_038428732.1 → XP_038284660.1  insulin receptor isoform X3

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Conserved Domains (5) summary
    cd05061
    Location:820 → 1107
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:671 → 748
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:23 → 142
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:164 → 277
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:744 → 791
    Insulin_TMD; Insulin receptor trans-membrane segment

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    51751620..51886677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038504972.1 → XP_038360900.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    52194853..52330054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038631557.1 → XP_038487485.1  

    Conserved Domains (5) summary
    cd05061
    Location:966 → 1253
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:817 → 894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:142 → 300
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:322 → 435
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:890 → 937
    Insulin_TMD; Insulin receptor trans-membrane segment

  2. XM_038631556.1 → XP_038487484.1  

    Conserved Domains (5) summary
    cd05061
    Location:978 → 1265
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:829 → 906
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:142 → 300
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:322 → 435
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:902 → 949
    Insulin_TMD; Insulin receptor trans-membrane segment

  3. XM_038631559.1 → XP_038487487.1  

    Conserved Domains (5) summary
    cd05061
    Location:805 → 1092
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:656 → 733
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:8 → 127
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:149 → 262
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:729 → 776
    Insulin_TMD; Insulin receptor trans-membrane segment

  4. XM_038631558.1 → XP_038487486.1  

    Conserved Domains (5) summary
    cd05061
    Location:820 → 1107
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:671 → 748
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:23 → 142
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:164 → 277
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:744 → 791
    Insulin_TMD; Insulin receptor trans-membrane segment

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    52425027..52560283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038567407.1 → XP_038423335.1  insulin receptor isoform X2

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Conserved Domains (5) summary
    cd05061
    Location:966 → 1253
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:817 → 894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:142 → 300
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:322 → 435
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:890 → 937
    Insulin_TMD; Insulin receptor trans-membrane segment

  2. XM_038567406.1 → XP_038423334.1  insulin receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Conserved Domains (5) summary
    cd05061
    Location:978 → 1265
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:829 → 906
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:142 → 300
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:322 → 435
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:902 → 949
    Insulin_TMD; Insulin receptor trans-membrane segment

  3. XM_038567409.1 → XP_038423337.1  insulin receptor isoform X4

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Conserved Domains (5) summary
    cd05061
    Location:805 → 1092
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:656 → 733
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:8 → 127
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:149 → 262
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:729 → 776
    Insulin_TMD; Insulin receptor trans-membrane segment

  4. XM_038567408.1 → XP_038423336.1  insulin receptor isoform X3

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Conserved Domains (5) summary
    cd05061
    Location:820 → 1107
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:671 → 748
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:23 → 142
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:164 → 277
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:744 → 791
    Insulin_TMD; Insulin receptor trans-membrane segment

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    51822227..51957301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038455158.1 → XP_038311086.1  insulin receptor isoform X2

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Conserved Domains (5) summary
    cd05061
    Location:966 → 1253
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:817 → 894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:142 → 300
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:322 → 435
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:890 → 937
    Insulin_TMD; Insulin receptor trans-membrane segment

  2. XM_038455157.1 → XP_038311085.1  insulin receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Conserved Domains (5) summary
    cd05061
    Location:978 → 1265
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:829 → 906
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:142 → 300
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:322 → 435
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:902 → 949
    Insulin_TMD; Insulin receptor trans-membrane segment

  3. XM_038455159.1 → XP_038311087.1  insulin receptor isoform X4

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Conserved Domains (5) summary
    cd05061
    Location:805 → 1092
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:656 → 733
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:8 → 127
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:149 → 262
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:729 → 776
    Insulin_TMD; Insulin receptor trans-membrane segment

  4. XM_022407090.2 → XP_022262798.2  insulin receptor isoform X3

    UniProtKB/TrEMBL
    A0A8I3PNN8
    Conserved Domains (5) summary
    cd05061
    Location:820 → 1107
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:671 → 748
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:23 → 142
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:164 → 277
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:744 → 791
    Insulin_TMD; Insulin receptor trans-membrane segment
Nucleotide Protein
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