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Grip91 Gamma-tubulin ring protein 91 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48481, updated on 8-Feb-2025

Summary

Official Symbol
Grip91provided by FlyBase
Official Full Name
Gamma-tubulin ring protein 91provided by FlyBase
Primary source
FLYBASE:FBgn0001612
Locus tag
Dmel_CG10988
See related
AllianceGenome:FB:FBgn0001612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO03040301.197; CG10988; dd4; Dd4; Dgrip9; dGRIP91; Dgrip91; DGrip91; Dgrips91; Dmel\CG10988; GCP3; GRIP91; l(1)d deg-4; l(1)d.deg.-4; l(1)d.deg.4; l(1)dd4; l(1)G0122
Summary
Enables gamma-tubulin binding activity. Contributes to microtubule minus-end binding activity. Involved in male meiotic nuclear division; meiotic spindle organization; and mitotic spindle-templated microtubule nucleation. Part of gamma-tubulin ring complex and gamma-tubulin small complex. Colocalizes with centrosome and mitotic spindle. Is expressed in adult head. Orthologous to human TUBGCP3 (tubulin gamma complex component 3). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See Grip91 in Genome Data Viewer
Location:
12B4-12B4; 1-45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13736570..13744683, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13630603..13638716, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mutagen-sensitive 101 Neighboring gene garnet Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42861 Neighboring gene Programmed cell death 4 Neighboring gene antisense RNA:CR43833

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to microtubule minus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule nucleation IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle-templated microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of gamma-tubulin ring complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of gamma-tubulin small complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of gamma-tubulin small complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Gamma-tubulin ring protein 91
Names
CG10988-PA
Dgrip91
Dgrips91
Grip91-PA
lethal (1) discs degenerate 4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13736570..13744683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080180.4NP_524919.2  Gamma-tubulin ring protein 91 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524919.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VY94, Q9XYP8
    Related
    FBpp0073672
    Conserved Domains (1) summary
    pfam04130
    Location:236758
    Spc97_Spc98; Spc97 / Spc98 family