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CNOT2 CCR4-NOT transcription complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 4848, updated on 5-Jul-2020

Summary

Official Symbol
CNOT2provided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:7878
See related
Ensembl:ENSG00000111596 MIM:604909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOT2; CDC36; NOT2H; HSPC131; IDNADFS
Summary
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 13.7), skin (RPKM 12.9) and 25 other tissues See more
Orthologs

Genomic context

See CNOT2 in Genome Data Viewer
Location:
12q15
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (70242993..70354993)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (70636774..70748773)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene histone PARylation factor 1 pseudogene Neighboring gene long intergenic non-protein coding RNA 2821 Neighboring gene progenitor renewal associated non-coding RNA Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 4 Neighboring gene RNA, U4 small nuclear 65, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26456

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II transcription corepressor binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to poly(A)-specific ribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 2
Names
CCR4-associated factor 2
negative regulator of transcription 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199302.1NP_001186231.1  CCR4-NOT transcription complex subunit 2

    See identical proteins and their annotated locations for NP_001186231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA234384, AC025569, AK315715, BC002597
    Consensus CDS
    CCDS31857.1
    UniProtKB/Swiss-Prot
    Q9NZN8
    UniProtKB/TrEMBL
    A0A024RBD8, B2RDX7
    Related
    ENSP00000412091.3, ENST00000418359.7
    Conserved Domains (1) summary
    pfam04153
    Location:396519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  2. NM_001199303.1NP_001186232.1  CCR4-NOT transcription complex subunit 2

    See identical proteins and their annotated locations for NP_001186232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA234384, AC025569, AK095789, AK307479, BC002597
    Consensus CDS
    CCDS31857.1
    UniProtKB/Swiss-Prot
    Q9NZN8
    UniProtKB/TrEMBL
    A0A024RBD8, B3KTL6
    Related
    ENSP00000449260.1, ENST00000551043.5
    Conserved Domains (1) summary
    pfam04153
    Location:396519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  3. NM_014515.7NP_055330.1  CCR4-NOT transcription complex subunit 2

    See identical proteins and their annotated locations for NP_055330.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC025569, AC092881
    Consensus CDS
    CCDS31857.1
    UniProtKB/Swiss-Prot
    Q9NZN8
    UniProtKB/TrEMBL
    A0A024RBD8
    Related
    ENSP00000450318.2, ENST00000552231.6
    Conserved Domains (1) summary
    pfam04153
    Location:396519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

RNA

  1. NR_037615.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate internal exon compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA234384, AC025569, AK307479, BC002597

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    70242993..70354993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448986.1XP_024304754.1  CCR4-NOT transcription complex subunit 2 isoform X6

    Conserved Domains (1) summary
    pfam04153
    Location:250373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  2. XM_024448987.1XP_024304755.1  CCR4-NOT transcription complex subunit 2 isoform X7

    Conserved Domains (1) summary
    pfam04153
    Location:239362
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  3. XM_006719429.3XP_006719492.1  CCR4-NOT transcription complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006719492.1

    UniProtKB/TrEMBL
    F8VV52
    Related
    ENSP00000449659.1, ENST00000548159.5
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  4. XM_017019354.1XP_016874843.1  CCR4-NOT transcription complex subunit 2 isoform X6

    Conserved Domains (1) summary
    pfam04153
    Location:250373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  5. XM_017019353.1XP_016874842.1  CCR4-NOT transcription complex subunit 2 isoform X6

    Conserved Domains (1) summary
    pfam04153
    Location:250373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  6. XM_011538400.3XP_011536702.1  CCR4-NOT transcription complex subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_011536702.1

    Related
    ENSP00000448024.2, ENST00000550641.6
    Conserved Domains (1) summary
    pfam04153
    Location:376499
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  7. XM_017019349.1XP_016874838.1  CCR4-NOT transcription complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    F8VV52
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  8. XM_017019352.1XP_016874841.1  CCR4-NOT transcription complex subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam04153
    Location:376499
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  9. XM_017019348.1XP_016874837.1  CCR4-NOT transcription complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    F8VV52
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  10. XM_017019351.1XP_016874840.1  CCR4-NOT transcription complex subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam04153
    Location:376499
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  11. XM_017019350.1XP_016874839.1  CCR4-NOT transcription complex subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam04153
    Location:376499
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  12. XM_006719430.3XP_006719493.1  CCR4-NOT transcription complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006719493.1

    UniProtKB/TrEMBL
    F8VV52
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  13. XM_006719433.4XP_006719496.1  CCR4-NOT transcription complex subunit 2 isoform X5

    See identical proteins and their annotated locations for XP_006719496.1

    Conserved Domains (1) summary
    pfam04153
    Location:259382
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  14. XM_006719432.4XP_006719495.1  CCR4-NOT transcription complex subunit 2 isoform X4

    See identical proteins and their annotated locations for XP_006719495.1

    Conserved Domains (1) summary
    pfam04153
    Location:335458
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  15. XM_024448988.1XP_024304756.1  CCR4-NOT transcription complex subunit 2 isoform X8

  16. XM_011538399.1XP_011536701.1  CCR4-NOT transcription complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011536701.1

    UniProtKB/Swiss-Prot
    Q9NZN8
    UniProtKB/TrEMBL
    A0A024RBD8
    Conserved Domains (1) summary
    pfam04153
    Location:396519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

RNA

  1. XR_001748718.1 RNA Sequence

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