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OXTR oxytocin receptor [ Canis lupus familiaris (dog) ]

Gene ID: 484670, updated on 25-Jul-2026
Official Symbol
OXTRprovided by VGNC
Official Full Name
oxytocin receptorprovided by VGNC
Primary source
VGNC:VGNC:44206
See related
Ensembl:ENSCAFG00845010546 RGD:12350768
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See OXTR in Genome Data Viewer
Location:
chromosome: 20
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (9388927..9412408)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (9392409..9411729)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (9429314..9449013)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (9110306..9130001)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (9455823..9475105)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene rab GDP dissociation inhibitor beta-like Neighboring gene RAD18 E3 ubiquitin protein ligase Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene caveolin 3 Neighboring gene proteasome subunit alpha type-1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs. Persson ME, et al. Horm Behav, 2017 Sep. PMID 28765081
  2. Oxytocin receptors in dioestrous and anoestrous canine uteri. Tamminen TM, et al. Reprod Domest Anim, 2017 Feb. PMID 27966823
  3. Uterine and placental expression of canine oxytocin receptor during pregnancy and normal and induced parturition. Gram A, et al. Reprod Domest Anim, 2014 Jun. PMID 24947860
  4. Immunolocalisation and expression of oxytocin receptors and sex hormone-binding globulin in the testis and epididymis of dogs: correlation with sperm function. Dalmazzo A, et al. Reprod Fertil Dev, 2019 Aug. PMID 31046900
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immunolocalisation and expression of oxytocin receptors and sex hormone-binding globulin in the testis and epididymis of dogs: correlation with sperm function.
    Title: Immunolocalisation and expression of oxytocin receptors and sex hormone-binding globulin in the testis and epididymis of dogs: correlation with sperm function.
  2. Intranasal oxytocin treatment, an OXTR polymorphism and their interaction are associated with dogs' human-directed social skills, which can explain previously described breed differences in oxytocin response.
    Title: Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs.
  3. This study demonstrated the presence of OTR in myometrial smooth muscle cells, luminal epithelium, superficial glandular epithelium and stroma in the uterus of non-pregnant bitches
    Title: Oxytocin receptors in dioestrous and anoestrous canine uteri.
  4. These findings suggest involvement of OTR in the signalling cascade leading to the prepartum release of prostaglandins from the pregnant canine uterus.
    Title: Uterine and placental expression of canine oxytocin receptor during pregnancy and normal and induced parturition.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables oxytocin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables vasopressin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in maternal process involved in parturition IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of systemic arterial blood pressure by vasopressin IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
oxytocin receptor

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198659.1 → NP_001185588.1  oxytocin receptor

    See identical proteins and their annotated locations for NP_001185588.1

    Status: PROVISIONAL

    Source sequence(s)
    HM856596
    UniProtKB/TrEMBL
    A0A5K1UVD6, A0A8C0K5Q9
    Conserved Domains (2) summary
    pfam00001
    Location:56 → 324
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:46 → 144
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    9388927..9412408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038426447.1 → XP_038282375.1  oxytocin receptor isoform X3

    Conserved Domains (2) summary
    cd14964
    Location:112 → 138
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:111 → 374
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_038426444.1 → XP_038282372.1  oxytocin receptor isoform X2

    UniProtKB/TrEMBL
    A0A8I3RXZ9
    Related
    ENSCAFP00845014517.1, ENSCAFT00845018609.1
    Conserved Domains (2) summary
    cd14964
    Location:112 → 138
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:111 → 373
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_038426445.1 → XP_038282373.1  oxytocin receptor isoform X3

    Conserved Domains (2) summary
    cd14964
    Location:112 → 138
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:111 → 374
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_038426443.1 → XP_038282371.1  oxytocin receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I3N4T4
    Related
    ENSCAFP00845014495.1, ENSCAFT00845018581.1
    Conserved Domains (1) summary
    cd15387
    Location:111 → 406
    7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    9110306..9130001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    9455823..9475105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    9429314..9449013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    9392409..9411729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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