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NOS2 nitric oxide synthase 2 [ Homo sapiens (human) ]

Gene ID: 4843, updated on 14-Mar-2020

Summary

Official Symbol
NOS2provided by HGNC
Official Full Name
nitric oxide synthase 2provided by HGNC
Primary source
HGNC:HGNC:7873
See related
Ensembl:ENSG00000007171 MIM:163730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOS; INOS; NOS2A; HEP-NOS
Summary
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 10.3), appendix (RPKM 7.9) and 5 other tissues See more
Orthologs

Genomic context

See NOS2 in Genome Data Viewer
Location:
17q11.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (27756766..27800529, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26083792..26127555, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene carboxypeptidase D pseudogene 1 Neighboring gene galectin 9D, pseudogene Neighboring gene NOS2 5' regulatory region Neighboring gene LYR motif containing 9 Neighboring gene long intergenic non-protein coding RNA 1992 Neighboring gene CRISPRi-validated cis-regulatory element chr17.1404

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Susceptibility to malaria
MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
NHGRI GWA Catalog
Genome-wide association analysis identifies three psoriasis susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Ascorbate supplementation prevents the deleterious upregulation of iNOS and associated neuronal (MAP2) and astrocytic (GFAP) protein expression and structural changes caused by gp120 in human brain cell cultures PubMed
Envelope transmembrane glycoprotein gp41 env The amino terminus of HIV-1 gp41 induces nitric oxide synthase in human glial and astrocyte cultures and that causes the dysregulation of nitric oxide production PubMed
Tat tat HIV-1 Tat decreases expression of NOS2 (iNOS) in Leishmania-infected macrophages PubMed
tat HIV-1 Tat potentiates NMDA-evoked (Ca2+)I responses involve LRP and a Src family kinase via the NOS/sGC/PKG pathway PubMed
tat HIV-1 Tat induces iNOS in human astroglia and microglia through the activation of NF-kappaB and C/EBPbeta, an effect that may participate in the pathogenesis of HIV-associated dementia PubMed
tat HIV-1 Tat induces iNOS in rat brain injected with Tat through upregulation of TNF-alpha, suggesting a mechanism for Tat-induced CNS damage PubMed
tat HIV-1 Tat induces the expression of NOS-2 and NOS-3 which appears to be a mechanism for regulating Tat-mediated degradation of IkappaBalpha and activation of NFkappaB PubMed
tat HIV-1 Tat inhibits interferon-induced iNOS activity in a murine macrophage cell line PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates expression of six genes, APOE, CCL5, DGKK, GPX5, NOS2, and PXDNL PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
FMN binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NADP binding TAS
Traceable Author Statement
more info
PubMed 
NADPH-hemoprotein reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arginine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flavin adenine dinucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nitric-oxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
tetrahydrobiopterin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
arginine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arginine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cell redox homeostasis TAS
Traceable Author Statement
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to Gram-negative bacterium NAS
Non-traceable Author Statement
more info
PubMed 
defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response in mucosa NAS
Non-traceable Author Statement
more info
PubMed 
interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-8 secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
nitric oxide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
nitric oxide mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-cysteine S-nitrosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of killing of cells of other organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of leukocyte mediated cytotoxicity TAS
Traceable Author Statement
more info
PubMed 
prostaglandin secretion IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular respiration TAS
Traceable Author Statement
more info
PubMed 
regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to bacterium NAS
Non-traceable Author Statement
more info
PubMed 
response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cortical cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
peroxisomal matrix TAS
Traceable Author Statement
more info
 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nitric oxide synthase, inducible
Names
NOS, type II
hepatocyte NOS
inducible NO synthase
inducible NOS
nitric oxide synthase 2, inducible
nitric oxide synthase 2A (inducible, hepatocytes)
nitric oxide synthase, macrophage
peptidyl-cysteine S-nitrosylase NOS2
NP_000616.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011470.1 RefSeqGene

    Range
    5001..48764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000625.4NP_000616.3  nitric oxide synthase, inducible

    See identical proteins and their annotated locations for NP_000616.3

    Status: REVIEWED

    Source sequence(s)
    AC130289
    Consensus CDS
    CCDS11223.1
    UniProtKB/Swiss-Prot
    P35228
    Related
    ENSP00000327251.6, ENST00000313735.11
    Conserved Domains (4) summary
    COG0369
    Location:5381127
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:84496
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:541672
    Flavodoxin_1; Flavodoxin
    cl06868
    Location:7361132
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    27756766..27800529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153292.1: Suppressed sequence

    Description
    NM_153292.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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