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NEPN nephrocan [ Canis lupus familiaris (dog) ]

Gene ID: 484101, updated on 3-Apr-2024

Summary

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Official Symbol
NEPNprovided by VGNC
Official Full Name
nephrocanprovided by VGNC
Primary source
VGNC:VGNC:109294
See related
Ensembl:ENSCAFG00845006606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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Genomic context

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See NEPN in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (58019276..58040614)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (58638245..58659578)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (58392985..58414381)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (57920627..57941960)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (57761565..57782903)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene ROS proto-oncogene 1, receptor tyrosine kinase Neighboring gene discoidin, CUB and LCCL domain containing 1 Neighboring gene golgi associated PDZ and coiled-coil motif containing Neighboring gene NUS1 dehydrodolichyl diphosphate synthase subunit Neighboring gene ferritin light chain-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nephrocan, a novel member of the small leucine-rich repeat protein family, is an inhibitor of transforming growth factor-beta signaling. Mochida Y, et al. J Biol Chem, 2006 Nov 24. PMID 16990280

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nephrocan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416114.1 → NP_001403043.1  nephrocan

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000354

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    58019276..58040614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038654740.1 → XP_038510668.1  nephrocan isoform X2

    Conserved Domains (3) summary
    PRK15370
    Location:1 → 205
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:150 → 173
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:177 → 400
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_038654739.1 → XP_038510667.1  nephrocan isoform X1

    UniProtKB/TrEMBL
    A0A8C0L9Q1, A0A8C0N3C8, A0A8C0Q085, A0A8I3MV71
    Related
    ENSCAFP00845009148.1, ENSCAFT00845011718.1
    Conserved Domains (3) summary
    PRK15370
    Location:32 → 321
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:188 → 211
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:215 → 438
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. XM_038654741.1 → XP_038510669.1  nephrocan isoform X3

    UniProtKB/TrEMBL
    A0A8C0N3C8
    Conserved Domains (2) summary
    sd00033
    Location:125 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:152 → 375
    PPP1R42; protein phosphatase 1 regulatory subunit 42

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    57920627..57941960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038465972.1 → XP_038321900.1  nephrocan isoform X2

    Conserved Domains (3) summary
    PRK15370
    Location:1 → 205
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:150 → 173
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:177 → 400
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_038465971.1 → XP_038321899.1  nephrocan isoform X1

    Conserved Domains (3) summary
    PRK15370
    Location:32 → 321
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:188 → 211
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:215 → 438
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. XM_038465973.1 → XP_038321901.1  nephrocan isoform X3

    Conserved Domains (2) summary
    sd00033
    Location:125 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:152 → 375
    PPP1R42; protein phosphatase 1 regulatory subunit 42

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    57761565..57782903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038590944.1 → XP_038446872.1  nephrocan isoform X2

    Conserved Domains (3) summary
    PRK15370
    Location:1 → 205
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:150 → 173
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:177 → 400
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_038590943.1 → XP_038446871.1  nephrocan isoform X1

    Conserved Domains (3) summary
    PRK15370
    Location:32 → 321
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:188 → 211
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:215 → 438
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. XM_038590945.1 → XP_038446873.1  nephrocan isoform X3

    Conserved Domains (2) summary
    sd00033
    Location:125 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:152 → 375
    PPP1R42; protein phosphatase 1 regulatory subunit 42

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    58392985..58414381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038526644.1 → XP_038382572.1  nephrocan isoform X2

    UniProtKB/TrEMBL
    A0A8C0N3C8
    Conserved Domains (3) summary
    PRK15370
    Location:1 → 205
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:150 → 173
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:177 → 400
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_038526643.1 → XP_038382571.1  nephrocan isoform X1

    UniProtKB/TrEMBL
    A0A8C0L9Q1, A0A8C0N3C8, A0A8C0Q085, A0A8I3MV71
    Conserved Domains (3) summary
    PRK15370
    Location:32 → 321
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:188 → 211
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:215 → 438
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. XM_038526645.1 → XP_038382573.1  nephrocan isoform X3

    UniProtKB/TrEMBL
    A0A8C0N3C8
    Conserved Domains (2) summary
    sd00033
    Location:125 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:152 → 375
    PPP1R42; protein phosphatase 1 regulatory subunit 42

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    58638245..58659578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022419424.2 → XP_022275132.1  nephrocan isoform X2

    Conserved Domains (3) summary
    PRK15370
    Location:1 → 205
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:150 → 173
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:177 → 400
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_541218.5 → XP_541218.2  nephrocan isoform X1

    UniProtKB/TrEMBL
    A0A8C0L9Q1, A0A8C0N3C8, A0A8C0Q085, A0A8I3MV71
    Conserved Domains (3) summary
    PRK15370
    Location:32 → 321
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:188 → 211
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:215 → 438
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. XM_022419425.2 → XP_022275133.1  nephrocan isoform X3

    UniProtKB/TrEMBL
    A0A8C0N3C8
    Conserved Domains (2) summary
    sd00033
    Location:125 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:152 → 375
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein
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