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PDE10A phosphodiesterase 10A [ Canis lupus familiaris (dog) ]

Gene ID: 484073, updated on 25-Jul-2026
Official Symbol
PDE10Aprovided by VGNC
Official Full Name
phosphodiesterase 10Aprovided by VGNC
Primary source
VGNC:VGNC:44345
See related
Ensembl:ENSCAFG00845004510 RGD:12188108
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See PDE10A in Genome Data Viewer
Location:
chromosome: 1
Exon count:
28
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (53634410..54231358, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (54243884..54542326, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (54012303..54310827, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (53531754..53830179, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (53379457..53678753, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene chromosome 1 C6orf118 homolog Neighboring gene uncharacterized LOC119870150 Neighboring gene uncharacterized LOC102152011 Neighboring gene glutathione S-transferase kappa 1-like Neighboring gene U1 spliceosomal RNA Neighboring gene T-box transcription factor T

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
XP_038321768.1

Length

  • 1073
XP_038382448.1
XP_038446738.1

Length

  • 1073
XP_038510530.1
XP_038510531.1
XP_038510532.1
XP_038510533.1
XP_038510534.1
XP_038510535.1
XP_038510536.1
XP_541190.4

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    53634410..54231358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038654605.1 → XP_038510533.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4

    UniProtKB/TrEMBL
    A0A8I3MXY7
    Related
    ENSCAFP00845006525.1, ENSCAFT00845008294.1
    Conserved Domains (3) summary
    smart00065
    Location:271 → 426
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:518 → 750
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:95 → 238
    GAF; GAF domain

  2. XM_038654603.1 → XP_038510531.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2

    UniProtKB/TrEMBL
    A0A8I3MSV3
    Conserved Domains (3) summary
    smart00065
    Location:336 → 491
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:583 → 815
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:160 → 303
    GAF; GAF domain

  3. XM_038654602.1 → XP_038510530.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1

    UniProtKB/TrEMBL
    A0A8I3MV27
    Related
    ENSCAFP00845006466.1, ENSCAFT00845008228.1
    Conserved Domains (3) summary
    smart00065
    Location:554 → 709
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:801 → 1033
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:378 → 521
    GAF; GAF domain

  4. XM_038654607.1 → XP_038510535.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6

    UniProtKB/TrEMBL
    A0A8I3MXY7
    Related
    ENSCAFP00845006485.1, ENSCAFT00845008250.1
    Conserved Domains (3) summary
    smart00065
    Location:261 → 416
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:508 → 740
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:85 → 228
    GAF; GAF domain

  5. XM_038654608.1 → XP_038510536.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

    UniProtKB/TrEMBL
    A0A8I3MQP8, A0A8I3MXY7
    Related
    ENSCAFP00845006500.1, ENSCAFT00845008266.1
    Conserved Domains (3) summary
    smart00065
    Location:260 → 415
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:507 → 739
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:84 → 227
    GAF; GAF domain

  6. XM_038654606.1 → XP_038510534.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5

    UniProtKB/TrEMBL
    A0A8I3MXY7
    Conserved Domains (3) summary
    smart00065
    Location:268 → 423
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:515 → 747
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:92 → 235
    GAF; GAF domain

  7. XM_038654604.1 → XP_038510532.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3

    UniProtKB/TrEMBL
    A0A8I3MXY7
    Conserved Domains (3) summary
    smart00065
    Location:274 → 429
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:521 → 753
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:98 → 241
    GAF; GAF domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    53531754..53830179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038465840.1 → XP_038321768.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    53379457..53678753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038590810.1 → XP_038446738.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    54012303..54310827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038526520.1 → XP_038382448.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    54243884..54542326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_541190.7 → XP_541190.4  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1

    Conserved Domains (3) summary
    smart00065
    Location:554 → 709
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:801 → 1033
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:378 → 521
    GAF; GAF domain
Nucleotide Protein
Heading Accession and Version

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