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TNFRSF11A TNF receptor superfamily member 11a [ Canis lupus familiaris (dog) ]

Gene ID: 483957, updated on 27-Jun-2026
Official Symbol
TNFRSF11Aprovided by VGNC
Official Full Name
TNF receptor superfamily member 11aprovided by VGNC
Primary source
VGNC:VGNC:47654
See related
Ensembl:ENSCAFG00845000032 RGD:12077036
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
RANK
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See TNFRSF11A in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (14362189..14416396, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (15469086..15523233, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (14578257..14632411, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (14398162..14452574, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (14331546..14385610, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111094566 Neighboring gene zinc finger CCHC-type containing 2 Neighboring gene uncharacterized LOC119870710 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene tubulin alpha-8 chain-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Immunohistochemical and quantitative RT-PCR methods to assess RANK expression in normal and neoplastic canine mammary gland. Sánchez-Céspedes R, et al. J Vet Diagn Invest, 2018 Jan. PMID 29020879, Free PMC Article
  2. Osteoprotegerin activates osteosarcoma cells that co-express RANK and RANKL. Marley K, et al. Exp Cell Res, 2015 Oct 15. PMID 26254896
  3. Immunohistochemical localization of RANK, RANKL and OPG in healthy and arthritic canine elbow joints. Spahni AI, et al. Vet Surg, 2009 Aug. PMID 19674422
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RANK gene was found at similar expression levels in all canine mammary ME and LE cell lines studied; RANK expression was found in normal, dysplastic, and neoplastic canine mammary tissues and cell lines, in both ME and LE cell populations.
    Title: Immunohistochemical and quantitative RT-PCR methods to assess RANK expression in normal and neoplastic canine mammary gland.
  2. Canine osteosarcoma tumors and cell lines co-express mRNA for both RANK and RANKL.
    Title: Osteoprotegerin activates osteosarcoma cells that co-express RANK and RANKL.
  3. The activity of the nuclear factor-kappaB ligand-osteoprotegerin (RANK-RANKL-OPG) system in bone remodeling in dogs with osteoarthrtiis of the elbow is reported.
    Title: Immunohistochemical localization of RANK, RANKL and OPG in healthy and arthritic canine elbow joints.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lymph node development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multinuclear osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tumor necrosis factor receptor superfamily member 11A
Names
receptor activator of nuclear factor-kappa B

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    14362189..14416396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653574.1 → XP_038509502.1  tumor necrosis factor receptor superfamily member 11A

    UniProtKB/TrEMBL
    A0A8I3MES0
    Related
    ENSCAFP00845000033.1, ENSCAFT00845000048.1
    Conserved Domains (1) summary
    cd13411
    Location:33 → 195
    TNFRSF11A; Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), also known as receptor activator of nuclear factor-kappaB (RANK)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    14398162..14452574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038465095.1 → XP_038321023.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    14331546..14385610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038589768.1 → XP_038445696.1  

    Conserved Domains (1) summary
    cd13411
    Location:33 → 195
    TNFRSF11A; Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), also known as receptor activator of nuclear factor-kappaB (RANK)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    14578257..14632411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038529560.1 → XP_038385488.1  tumor necrosis factor receptor superfamily member 11A

    UniProtKB/TrEMBL
    A0A8I3MES0

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    15469086..15523233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005615669.4 → XP_005615726.2  tumor necrosis factor receptor superfamily member 11A

    UniProtKB/TrEMBL
    A0A8I3MES0
    Conserved Domains (1) summary
    cd13411
    Location:33 → 195
    TNFRSF11A; Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), also known as receptor activator of nuclear factor-kappaB (RANK)
Nucleotide Protein
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