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NNMT nicotinamide N-methyltransferase [ Homo sapiens (human) ]

Gene ID: 4837, updated on 13-May-2022

Summary

Official Symbol
NNMTprovided by HGNC
Official Full Name
nicotinamide N-methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:7861
See related
Ensembl:ENSG00000166741 MIM:600008; AllianceGenome:HGNC:7861
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 188.3), appendix (RPKM 69.3) and 10 other tissues See more
Orthologs
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Genomic context

See NNMT in Genome Data Viewer
Location:
11q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (114257806..114313536)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (114268171..114323905)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (114128528..114184258)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6346 Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene Sharpr-MPRA regulatory region 4637 Neighboring gene uncharacterized LOC101928940 Neighboring gene uncharacterized LOC107984391 Neighboring gene chromosome 11 open reading frame 71

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of nicotinamide N-methyltransferase (NNMT) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nicotinamide N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nicotinamide N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nicotinamide N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nicotinamide N-methyltransferase activity TAS
Traceable Author Statement
more info
 
enables pyridine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
 
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in methylation TAS
Traceable Author Statement
more info
 
involved_in nicotinamide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of histone H3-K4 methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nicotinamide N-methyltransferase
NP_001358974.1
NP_001358975.1
NP_001358976.1
NP_006160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372045.1NP_001358974.1  nicotinamide N-methyltransferase

    Status: REVIEWED

    Source sequence(s)
    AP002518
    Conserved Domains (1) summary
    pfam01234
    Location:2259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family
  2. NM_001372046.1NP_001358975.1  nicotinamide N-methyltransferase

    Status: REVIEWED

    Source sequence(s)
    AP002518
    Conserved Domains (1) summary
    pfam01234
    Location:2259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family
  3. NM_001372047.1NP_001358976.1  nicotinamide N-methyltransferase

    Status: REVIEWED

    Source sequence(s)
    AP002518
    Related
    ENSP00000441434.1, ENST00000535401.5
    Conserved Domains (1) summary
    pfam01234
    Location:2259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family
  4. NM_006169.3NP_006160.1  nicotinamide N-methyltransferase

    See identical proteins and their annotated locations for NP_006160.1

    Status: REVIEWED

    Source sequence(s)
    AP002518
    Consensus CDS
    CCDS8368.1
    UniProtKB/Swiss-Prot
    P40261
    UniProtKB/TrEMBL
    Q6FH49
    Related
    ENSP00000299964.3, ENST00000299964.4
    Conserved Domains (1) summary
    pfam01234
    Location:2259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RNA

  1. NR_164073.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP002518

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    114257806..114313536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    114268171..114323905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)