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NMT1 N-myristoyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 4836, updated on 7-Jun-2020

Summary

Official Symbol
NMT1provided by HGNC
Official Full Name
N-myristoyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:7857
See related
Ensembl:ENSG00000136448 MIM:160993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NMT
Summary
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]
Expression
Ubiquitous expression in brain (RPKM 21.5), thyroid (RPKM 17.0) and 25 other tissues See more
Orthologs

Genomic context

See NMT1 in Genome Data Viewer
Location:
17q21.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (45061317..45109016)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43138322..43186384)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987243 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene phospholipase C delta 3 Neighboring gene microRNA 6784 Neighboring gene acyl-CoA binding domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of N-myristoyltransferase 1 (NMT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef is identified to have a physical interaction with N-myristoyltransferase 1 (NMT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
nef The N-terminal glycine of HIV-1 Nef is myristoylated by N-myristoyltransferase PubMed
nef p65 N-myristoyltransferase isoform 1 coimmunoprecipitates with HIV-1 Nef in experiments using antibodies to Nef, and this interaction requires an intact myristoylation signal in Nef PubMed
matrix gag NMR studies of membrane binding-defective V7R and L8A HIV-1 Matrix mutants reveal minor structural changes that appear to be responsible for stabilizing the myristate-sequestered (myr(s)) species and inhibiting exposure PubMed
gag HIV-1 Matrix is myristoylated on its N-terminal glycine residue by N-myristoyltransferase, a chemical modification important for membrane targeting of Gag/Matrix, for facilitating Matrix multimerization, and for virus particle formation and budding PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycylpeptide N-tetradecanoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
myristoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
myristoyltransferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
glycylpeptide N-tetradecanoyltransferase 1
Names
alternative, short form NMT-S
long form, NMT-L
myristoyl-CoA:protein N-myristoyltransferase 1
type I N-myristoyltransferase
NP_066565.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021079.5NP_066565.1  glycylpeptide N-tetradecanoyltransferase 1

    See identical proteins and their annotated locations for NP_066565.1

    Status: VALIDATED

    Source sequence(s)
    AC002117, AC116493, BC006538, BC006569
    Consensus CDS
    CCDS11494.1
    UniProtKB/Swiss-Prot
    P30419
    Related
    ENSP00000258960.2, ENST00000258960.7
    Conserved Domains (1) summary
    cl27359
    Location:86484
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    45061317..45109016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002958013.1 RNA Sequence

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