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NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 [ Homo sapiens (human) ]

Gene ID: 4835, updated on 12-Jan-2019

Summary

Official Symbol
NQO2provided by HGNC
Official Full Name
N-ribosyldihydronicotinamide:quinone reductase 2provided by HGNC
Primary source
HGNC:HGNC:7856
See related
Ensembl:ENSG00000124588 MIM:160998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QR2; DHQV; DIA6; NMOR2
Summary
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Broad expression in kidney (RPKM 43.3), fat (RPKM 18.6) and 24 other tissues See more
Orthologs

Genomic context

See NQO2 in Genome Data Viewer
Location:
6p25.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (2999816..3019876)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (3000067..3019997)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SERPINB6-LINC01011 intergenic CAGE-defined mid-level expression enhancer Neighboring gene uncharacterized LOC105374888 Neighboring gene long intergenic non-protein coding RNA 1011 Neighboring gene HIV-1 Tat specific factor 1 pseudogene 2 Neighboring gene uncharacterized LOC101927759 Neighboring gene family with sequence similarity 136 member B, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
  • Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, organism-specific biosystemPhotodynamic therapy may induce an antioxidant response mediated by NFE2L2.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
NAD(P)H dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride ion binding IDA
Inferred from Direct Assay
more info
PubMed 
dihydronicotinamide riboside quinone reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
dihydronicotinamide riboside quinone reductase activity TAS
Traceable Author Statement
more info
 
electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
electron transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
melatonin binding IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on other nitrogenous compounds as donors IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
resveratrol binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ribosyldihydronicotinamide dehydrogenase [quinone]
Names
NAD(P)H dehydrogenase, quinone 2
NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2
NAD(P)H quinone dehydrogenase 2
NRH:quinone oxidoreductase 2
quinone reductase 2
ribosyldihydronicotinamide dehydrogenase
NP_000895.2
NP_001277150.1
NP_001277151.1
NP_001305869.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034013.1 RefSeqGene

    Range
    5001..25061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000904.4NP_000895.2  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    See identical proteins and their annotated locations for NP_000895.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three exons in the 5' UTR compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK056981, AK311746, AL133351, BC006096, CD014013
    Consensus CDS
    CCDS4481.1
    UniProtKB/Swiss-Prot
    P16083
    UniProtKB/TrEMBL
    B3KPX6
    Related
    ENSP00000369822.4, ENST00000380455.8
    Conserved Domains (1) summary
    pfam02525
    Location:5212
    Flavodoxin_2; Flavodoxin-like fold
  2. NM_001290221.1NP_001277150.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    See identical proteins and their annotated locations for NP_001277150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK056981, AK311746, AL133351, CD014013, J02888
    Consensus CDS
    CCDS4481.1
    UniProtKB/Swiss-Prot
    P16083
    UniProtKB/TrEMBL
    B3KPX6
    Related
    ENSP00000337773.2, ENST00000338130.6
    Conserved Domains (1) summary
    pfam02525
    Location:5212
    Flavodoxin_2; Flavodoxin-like fold
  3. NM_001290222.1NP_001277151.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2

    See identical proteins and their annotated locations for NP_001277151.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three exons in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AL133351, BI670476, CD014013
    Consensus CDS
    CCDS75388.1
    UniProtKB/TrEMBL
    Q5TD07
    Related
    ENSP00000369821.4, ENST00000380454.8
    Conserved Domains (1) summary
    pfam02525
    Location:5174
    Flavodoxin_2; Flavodoxin-like fold
  4. NM_001318940.1NP_001305869.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK056981, AL133351, BI333292, CD014013
    Consensus CDS
    CCDS4481.1
    UniProtKB/Swiss-Prot
    P16083
    UniProtKB/TrEMBL
    B3KPX6
    Related
    ENSP00000369795.1, ENST00000380430.5
    Conserved Domains (1) summary
    pfam02525
    Location:5212
    Flavodoxin_2; Flavodoxin-like fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    2999816..3019876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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