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CARD14 caspase recruitment domain family member 14 [ Canis lupus familiaris (dog) ]

Gene ID: 483353, updated on 25-Jul-2026
Official Symbol
CARD14provided by VGNC
Official Full Name
caspase recruitment domain family member 14provided by VGNC
Primary source
VGNC:VGNC:38715
See related
Ensembl:ENSCAFG00845013259 RGD:12396481
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
Try the new Gene page
Try the new Transcripts and proteins table
See CARD14 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (2179981..2208232, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (2187504..2215755, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (2410129..2438381, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (2203394..2231638, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (2328838..2357073, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 11 Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene dual specificity protein phosphatase 5-like

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
PubMed 
Preferred Names
caspase recruitment domain-containing protein 14

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    2179981..2208232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038675494.1XP_038531422.1  caspase recruitment domain-containing protein 14 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NFE1
    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  2. XM_038675491.1XP_038531419.1  caspase recruitment domain-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NFE1
    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  3. XM_038675493.1XP_038531421.1  caspase recruitment domain-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NFE1
    Related
    ENSCAFP00845018557.1, ENSCAFT00845023641.1
    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:582654
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:679740
    SH3; Src Homology 3 domain superfamily
  4. XM_038675492.1XP_038531420.1  caspase recruitment domain-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NFE1
    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  5. XM_038675495.1XP_038531423.1  caspase recruitment domain-containing protein 14 isoform X4

    Conserved Domains (5) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15694
    Location:752816
    Med26_M; Mediator complex subunit 26 middle domain
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    2203394..2231638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038484724.1XP_038340652.1  

    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  2. XM_038484721.1XP_038340649.1  

    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  3. XM_038484723.1XP_038340651.1  

    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:582654
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:679740
    SH3; Src Homology 3 domain superfamily
  4. XM_038484722.1XP_038340650.1  

    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  5. XM_038484725.1XP_038340653.1  

    Conserved Domains (5) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15694
    Location:752816
    Med26_M; Mediator complex subunit 26 middle domain
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    2328838..2357073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038610378.1XP_038466306.1  

    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  2. XM_038610375.1XP_038466303.1  

    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  3. XM_038610377.1XP_038466305.1  

    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:582654
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:679740
    SH3; Src Homology 3 domain superfamily
  4. XM_038610376.1XP_038466304.1  

    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  5. XM_038610379.1XP_038466307.1  

    Conserved Domains (5) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15694
    Location:752816
    Med26_M; Mediator complex subunit 26 middle domain
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    2410129..2438381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038546370.1XP_038402298.1  caspase recruitment domain-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NFE1
  2. XM_038546371.1XP_038402299.1  caspase recruitment domain-containing protein 14 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NFE1
  3. XM_038546368.1XP_038402296.1  caspase recruitment domain-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NFE1
  4. XM_038546369.1XP_038402297.1  caspase recruitment domain-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NFE1
  5. XM_038546372.1XP_038402300.1  caspase recruitment domain-containing protein 14 isoform X4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    2187504..2215755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038623753.1XP_038479681.1  caspase recruitment domain-containing protein 14 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NFE1
    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  2. XM_038623728.1XP_038479656.1  caspase recruitment domain-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NFE1
    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  3. XM_038623744.1XP_038479672.1  caspase recruitment domain-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NFE1
    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:582654
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:679740
    SH3; Src Homology 3 domain superfamily
  4. XM_022422641.2XP_022278349.1  caspase recruitment domain-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NFE1
    Conserved Domains (4) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily
  5. XM_038623762.1XP_038479690.1  caspase recruitment domain-containing protein 14 isoform X4

    Conserved Domains (5) summary
    COG1196
    Location:134409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:583655
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15694
    Location:752816
    Med26_M; Mediator complex subunit 26 middle domain
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:680741
    SH3; Src Homology 3 domain superfamily