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NME3 NME/NM23 nucleoside diphosphate kinase 3 [ Homo sapiens (human) ]

Gene ID: 4832, updated on 5-Sep-2021

Summary

Official Symbol
NME3provided by HGNC
Official Full Name
NME/NM23 nucleoside diphosphate kinase 3provided by HGNC
Primary source
HGNC:HGNC:7851
See related
Ensembl:ENSG00000103024 MIM:601817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDPKC; NDPK-C; NM23H3; DR-nm23; NM23-H3; c371H6.2
Expression
Ubiquitous expression in prostate (RPKM 24.8), fat (RPKM 18.6) and 25 other tissues See more
Orthologs
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Genomic context

See NME3 in Genome Data Viewer
Location:
16p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1770320..1771750, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1820321..1821710, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene uncharacterized LOC101929480 Neighboring gene microRNA 3177 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0516

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleoside diphosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nucleoside diphosphate kinase 3
Names
NDK 3
NDP kinase 3
NDP kinase C
non-metastatic cells 3, protein expressed in
nucleoside diphosphate kinase C
NP_002504.2
XP_005255389.1
XP_011520805.1
XP_011520806.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002513.3NP_002504.2  nucleoside diphosphate kinase 3 precursor

    See identical proteins and their annotated locations for NP_002504.2

    Status: VALIDATED

    Source sequence(s)
    AC012180
    Consensus CDS
    CCDS10443.1
    UniProtKB/Swiss-Prot
    Q13232
    Related
    ENSP00000219302.3, ENST00000219302.8
    Conserved Domains (1) summary
    cd04413
    Location:22151
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1770320..1771750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522503.2XP_011520805.1  nucleoside diphosphate kinase 3 isoform X1

    Conserved Domains (2) summary
    cl00335
    Location:22169
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
    pfam00334
    Location:22157
    NDK; Nucleoside diphosphate kinase
  2. XM_011522504.2XP_011520806.1  nucleoside diphosphate kinase 3 isoform X3

    Related
    ENSP00000456160.1, ENST00000564628.1
    Conserved Domains (1) summary
    cl00335
    Location:2260
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
  3. XM_005255332.4XP_005255389.1  nucleoside diphosphate kinase 3 isoform X2

    Conserved Domains (2) summary
    cd04413
    Location:22128
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
    pfam00334
    Location:22128
    NDK; Nucleoside diphosphate kinase
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