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PIAS3 protein inhibitor of activated STAT 3 [ Canis lupus familiaris (dog) ]

Gene ID: 483160, updated on 5-Mar-2024

Summary

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Official Symbol
PIAS3provided by VGNC
Official Full Name
protein inhibitor of activated STAT 3provided by VGNC
Primary source
VGNC:VGNC:44521
See related
Ensembl:ENSCAFG00845010343
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See PIAS3 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (59647669..59658338, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (58119050..58129713, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (59307976..59318645, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (58520427..58531086, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (58581386..58592221, complement)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 115 Neighboring gene 40S ribosomal protein S15a-like Neighboring gene RNA polymerase III subunit C Neighboring gene nudix hydrolase 17 Neighboring gene ankyrin repeat domain 35 Neighboring gene integrin subunit alpha 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the JAK-STAT pathway in canine splenic hemangiosarcoma, thyroid carcinoma, mast cell tumor, and anal sac adenocarcinoma. Cletzer E, et al. Vet Immunol Immunopathol, 2020 Feb. PMID 31958674

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of the JAK-STAT pathway in canine splenic hemangiosarcoma, thyroid carcinoma, mast cell tumor, and anal sac adenocarcinoma.
    Title: Identification of the JAK-STAT pathway in canine splenic hemangiosarcoma, thyroid carcinoma, mast cell tumor, and anal sac adenocarcinoma.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SUMO ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 SUMO-protein ligase PIAS3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    59647669..59658338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038422966.1 → XP_038278894.1  E3 SUMO-protein ligase PIAS3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L2S1, A0A8I3NGF6, A0A8P0P4B4
    Related
    ENSCAFP00845014557.1, ENSCAFT00845018650.1
    Conserved Domains (3) summary
    cd16790
    Location:315 → 362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119 → 268
    PINIT; PINIT domain
    cl02640
    Location:2 → 27
    SAP; SAP domain

  2. XM_038422968.1 → XP_038278896.1  E3 SUMO-protein ligase PIAS3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0L2S1
    Conserved Domains (3) summary
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128 → 277
    PINIT; PINIT domain
    cl02640
    Location:11 → 36
    SAP; SAP domain

  3. XM_038422965.1 → XP_038278893.1  E3 SUMO-protein ligase PIAS3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0L2S1
    Related
    ENSCAFP00845014474.1, ENSCAFT00845018553.1
    Conserved Domains (3) summary
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128 → 277
    PINIT; PINIT domain
    cl02640
    Location:11 → 36
    SAP; SAP domain

  4. XM_038422967.1 → XP_038278895.1  E3 SUMO-protein ligase PIAS3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L2S1, A0A8I3NGF6, A0A8P0P4B4
    Conserved Domains (3) summary
    cd16790
    Location:315 → 362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119 → 268
    PINIT; PINIT domain
    cl02640
    Location:2 → 27
    SAP; SAP domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    58520427..58531086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038499450.1 → XP_038355378.1  E3 SUMO-protein ligase PIAS3 isoform X2

    Conserved Domains (3) summary
    cd16790
    Location:315 → 362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119 → 268
    PINIT; PINIT domain
    cl02640
    Location:2 → 27
    SAP; SAP domain

  2. XM_038499452.1 → XP_038355380.1  E3 SUMO-protein ligase PIAS3 isoform X3

    Conserved Domains (3) summary
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128 → 277
    PINIT; PINIT domain
    cl02640
    Location:11 → 36
    SAP; SAP domain

  3. XM_038499449.1 → XP_038355377.1  E3 SUMO-protein ligase PIAS3 isoform X1

    Conserved Domains (3) summary
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128 → 277
    PINIT; PINIT domain
    cl02640
    Location:11 → 36
    SAP; SAP domain

  4. XM_038499451.1 → XP_038355379.1  E3 SUMO-protein ligase PIAS3 isoform X2

    Conserved Domains (3) summary
    cd16790
    Location:315 → 362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119 → 268
    PINIT; PINIT domain
    cl02640
    Location:2 → 27
    SAP; SAP domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    58581386..58592221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038626110.1 → XP_038482038.1  E3 SUMO-protein ligase PIAS3 isoform X2

    Conserved Domains (3) summary
    cd16790
    Location:315 → 362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119 → 268
    PINIT; PINIT domain
    cl02640
    Location:2 → 27
    SAP; SAP domain

  2. XM_038626113.1 → XP_038482041.1  E3 SUMO-protein ligase PIAS3 isoform X3

    Conserved Domains (3) summary
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128 → 277
    PINIT; PINIT domain
    cl02640
    Location:11 → 36
    SAP; SAP domain

  3. XM_038626109.1 → XP_038482037.1  E3 SUMO-protein ligase PIAS3 isoform X1

    Conserved Domains (3) summary
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128 → 277
    PINIT; PINIT domain
    cl02640
    Location:11 → 36
    SAP; SAP domain

  4. XM_038626111.1 → XP_038482039.1  E3 SUMO-protein ligase PIAS3 isoform X2

    Conserved Domains (3) summary
    cd16790
    Location:315 → 362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119 → 268
    PINIT; PINIT domain
    cl02640
    Location:2 → 27
    SAP; SAP domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    59307976..59318645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038562026.1 → XP_038417954.1  E3 SUMO-protein ligase PIAS3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L2S1, A0A8I3NGF6, A0A8P0P4B4
    Conserved Domains (3) summary
    cd16790
    Location:315 → 362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119 → 268
    PINIT; PINIT domain
    cl02640
    Location:2 → 27
    SAP; SAP domain

  2. XM_038562028.1 → XP_038417956.1  E3 SUMO-protein ligase PIAS3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0L2S1
    Conserved Domains (3) summary
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128 → 277
    PINIT; PINIT domain
    cl02640
    Location:11 → 36
    SAP; SAP domain

  3. XM_038562025.1 → XP_038417953.1  E3 SUMO-protein ligase PIAS3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0L2S1
    Conserved Domains (3) summary
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128 → 277
    PINIT; PINIT domain
    cl02640
    Location:11 → 36
    SAP; SAP domain

  4. XM_038562027.1 → XP_038417955.1  E3 SUMO-protein ligase PIAS3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L2S1, A0A8I3NGF6, A0A8P0P4B4
    Conserved Domains (3) summary
    cd16790
    Location:315 → 362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119 → 268
    PINIT; PINIT domain
    cl02640
    Location:2 → 27
    SAP; SAP domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    58119050..58129713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038453298.1 → XP_038309226.1  E3 SUMO-protein ligase PIAS3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L2S1, A0A8I3NGF6, A0A8P0P4B4
    Conserved Domains (3) summary
    cd16790
    Location:315 → 362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119 → 268
    PINIT; PINIT domain
    cl02640
    Location:2 → 27
    SAP; SAP domain

  2. XM_022404933.2 → XP_022260641.1  E3 SUMO-protein ligase PIAS3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0L2S1
    Conserved Domains (3) summary
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128 → 277
    PINIT; PINIT domain
    cl02640
    Location:11 → 36
    SAP; SAP domain

  3. XM_854217.6 → XP_859310.2  E3 SUMO-protein ligase PIAS3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0L2S1
    Conserved Domains (3) summary
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128 → 277
    PINIT; PINIT domain
    cl02640
    Location:11 → 36
    SAP; SAP domain

  4. XM_005630723.4 → XP_005630780.1  E3 SUMO-protein ligase PIAS3 isoform X2

    See identical proteins and their annotated locations for XP_005630780.1

    UniProtKB/TrEMBL
    A0A8C0L2S1, A0A8I3NGF6, A0A8P0P4B4
    Conserved Domains (3) summary
    cd16790
    Location:315 → 362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119 → 268
    PINIT; PINIT domain
    cl02640
    Location:2 → 27
    SAP; SAP domain
Nucleotide Protein
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