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alphaTry alphaTrypsin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48316, updated on 6-Jul-2026
Official Symbol
alphaTryprovided by FlyBase
Official Full Name
alphaTrypsinprovided by FlyBase
Primary source
FLYBASE:FBgn0003863
Locus tag
Dmel_CG18444
See related
AllianceGenome:FB:FBgn0003863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alpha; alpha-Try; AlphaTry; CG18444; DmAlphaTry; Dmel\CG18444; SP102; Try
Summary
Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head and larval digestive system. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A1 and prostate cancer. Orthologous to several human genes including KLK12 (kallikrein related peptidase 12); KLK4 (kallikrein related peptidase 4); and KLK9 (kallikrein related peptidase 9). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See alphaTry in Genome Data Viewer
Location:
47F4-47F4; 2-64 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11344260..11345119, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7231765..7232624, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene etaTrypsin Neighboring gene thetaTrypsin Neighboring gene epsilonTrypsin Neighboring gene betaTrypsin

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A gene family in Drosophila melanogaster coding for trypsin-like enzymes. Davis CA, et al. Nucleic Acids Res, 1985 Sep 25. PMID 2414727, Free PMC Article
  2. Direct protein-protein interaction network for insecticide resistance based on subcellular localization analysis in Drosophila melanogaster. Zhang G, et al. J Environ Sci Health B, 2020. PMID 32567974
  3. A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes. Bozler J, et al. PLoS Genet, 2017 Oct. PMID 29084214, Free PMC Article
  4. Concerted evolution within a trypsin gene cluster in Drosophila. Wang S, et al. Mol Biol Evol, 1999 Sep. PMID 10486967
  5. Alkaline Ceramidase Mediates the Oxidative Stress Response in Drosophila melanogaster Through Sphingosine. Zhang CH, et al. J Insect Sci, 2019 May 1. PMID 31115476, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
alphaTrypsin
Names
CG18444-PA
alphaTry-PA
NP_476771.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11344260..11345119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057423.4 → NP_476771.1  alphaTrypsin

    See identical proteins and their annotated locations for NP_476771.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P04814, Q541G0, Q9V5Y2
    Related
    FBpp0087257
    Conserved Domains (1) summary
    smart00020
    Location:30 → 249
    Tryp_SPc; Trypsin-like serine protease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04814.1 P04814

Gene LinkOut

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