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XDH xanthine dehydrogenase [ Canis lupus familiaris (dog) ]

Gene ID: 483028, updated on 27-Jun-2026
Official Symbol
XDHprovided by VGNC
Official Full Name
xanthine dehydrogenaseprovided by VGNC
Primary source
VGNC:VGNC:48448
See related
Ensembl:ENSCAFG00845012424 RGD:12339104
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See XDH in Genome Data Viewer
Location:
chromosome: 17
Exon count:
36
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (25464496..25524534, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (24694965..24754929, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (24929639..24989647, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (24767742..24827816, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (24830189..24890224, complement)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119869732 Neighboring gene uncharacterized LOC111090424 Neighboring gene uncharacterized LOC119869775 Neighboring gene uncharacterized LOC119869680 Neighboring gene uncharacterized LOC102156534 Neighboring gene steroid 5 alpha-reductase 2 Neighboring gene mediator of cell motility 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Xanthine oxidase inhibition prevents atrial fibrillation in a canine model of atrial pacing-induced left ventricular dysfunction. Sakabe M, et al. J Cardiovasc Electrophysiol, 2012 Oct. PMID 22587612
  2. Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues. Lee MC, et al. Biochemistry, 2014 Oct 21. PMID 25243829, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that XDH (xanthine dehydrogenase) can be an important redox-regulated source of superoxide generation in ischemic tissue; conversion XDH to XO (xanthine oxidase) is not required to activate radical formation and subsequent tissue injury.
    Title: Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues.
  2. Xanthine oxidase inhibition suppresses atrial fibrillation promotion by preventing electrical and structural remodeling in the heart.
    Title: Xanthine oxidase inhibition prevents atrial fibrillation in a canine model of atrial pacing-induced left ventricular dysfunction.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables molybdopterin cofactor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables xanthine dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
xanthine dehydrogenase/oxidase
XP_005630370.1
XP_038308847.1
XP_038354560.1
XP_038354561.1
XP_038354562.1
XP_038417130.1
XP_038417131.1
XP_038417132.1
XP_038481179.1
XP_038481180.1
XP_038481181.1
XP_038547105.1
XP_038547106.1
XP_038547107.1
XP_540143.2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    25464496..25524534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038691178.1 → XP_038547106.1  xanthine dehydrogenase/oxidase isoform X2

    UniProtKB/TrEMBL
    A0A8I3NPM7
    Conserved Domains (1) summary
    PLN02906
    Location:23 → 1318
    PLN02906; xanthine dehydrogenase

  2. XM_038691177.1 → XP_038547105.1  xanthine dehydrogenase/oxidase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NBF8, A0A8I3NPM7
    Related
    ENSCAFP00845017384.1, ENSCAFT00845022107.1
    Conserved Domains (1) summary
    PLN02906
    Location:23 → 1319
    PLN02906; xanthine dehydrogenase

  3. XM_038691179.1 → XP_038547107.1  xanthine dehydrogenase/oxidase isoform X3

    UniProtKB/TrEMBL
    A0A8I3NPM7
    Conserved Domains (1) summary
    PLN02906
    Location:1 → 1198
    PLN02906; xanthine dehydrogenase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    24767742..24827816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038498633.1 → XP_038354561.1  

    Conserved Domains (1) summary
    PLN02906
    Location:23 → 1318
    PLN02906; xanthine dehydrogenase

  2. XM_038498632.1 → XP_038354560.1  

    Conserved Domains (1) summary
    PLN02906
    Location:23 → 1319
    PLN02906; xanthine dehydrogenase

  3. XM_038498634.1 → XP_038354562.1  

    Conserved Domains (1) summary
    PLN02906
    Location:1 → 1198
    PLN02906; xanthine dehydrogenase

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    24830189..24890224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038625252.1 → XP_038481180.1  

  2. XM_038625251.1 → XP_038481179.1  

  3. XM_038625253.1 → XP_038481181.1  

    Conserved Domains (1) summary
    PLN02906
    Location:1 → 1198
    PLN02906; xanthine dehydrogenase

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    24929639..24989647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038561203.1 → XP_038417131.1  xanthine dehydrogenase/oxidase isoform X2

    UniProtKB/TrEMBL
    A0A8C0LDB2, A0A8I3NPM7

  2. XM_038561202.1 → XP_038417130.1  xanthine dehydrogenase/oxidase isoform X1

    UniProtKB/TrEMBL
    A0A8C0LDB2, A0A8I3NPM7

  3. XM_038561204.1 → XP_038417132.1  xanthine dehydrogenase/oxidase isoform X3

    UniProtKB/TrEMBL
    A0A8C0LDB2
    Conserved Domains (1) summary
    PLN02906
    Location:1 → 1198
    PLN02906; xanthine dehydrogenase

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    24694965..24754929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005630313.4 → XP_005630370.1  xanthine dehydrogenase/oxidase isoform X2

    UniProtKB/TrEMBL
    A0A8C0LDB2, A0A8I3NPM7
    Conserved Domains (6) summary
    PLN02906
    Location:23 → 1318
    PLN02906; xanthine dehydrogenase
    pfam00941
    Location:233 → 413
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01315
    Location:588 → 694
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam01799
    Location:87 → 158
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:714 → 1237
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:420 → 524
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

  2. XM_540143.7 → XP_540143.2  xanthine dehydrogenase/oxidase isoform X1

    UniProtKB/TrEMBL
    A0A8C0LDB2, A0A8I3NPM7
    Conserved Domains (6) summary
    PLN02906
    Location:23 → 1319
    PLN02906; xanthine dehydrogenase
    pfam00941
    Location:233 → 413
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01315
    Location:589 → 695
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam01799
    Location:87 → 158
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:715 → 1238
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:420 → 524
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

  3. XM_038452919.1 → XP_038308847.1  xanthine dehydrogenase/oxidase isoform X3

    UniProtKB/TrEMBL
    A0A8C0LDB2
    Conserved Domains (1) summary
    PLN02906
    Location:1 → 1198
    PLN02906; xanthine dehydrogenase
Nucleotide Protein
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