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NKX6-1 NK6 homeobox 1 [ Homo sapiens (human) ]

Gene ID: 4825, updated on 22-May-2022

Summary

Official Symbol
NKX6-1provided by HGNC
Official Full Name
NK6 homeobox 1provided by HGNC
Primary source
HGNC:HGNC:7839
See related
Ensembl:ENSG00000163623 MIM:602563; AllianceGenome:HGNC:7839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKX6A; NKX6.1
Summary
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]
Expression
Biased expression in esophagus (RPKM 3.3), thyroid (RPKM 0.9) and 4 other tissues See more
Orthologs
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Genomic context

See NKX6-1 in Genome Data Viewer
Location:
4q21.23
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (84491985..84499292, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (87821981..87829288, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (85413138..85420445, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs680 Neighboring gene Sharpr-MPRA regulatory region 8005 Neighboring gene uncharacterized LOC102723338 Neighboring gene ribosomal protein L3 pseudogene 13 Neighboring gene CDP-diacylglycerol synthase 1 Neighboring gene Sharpr-MPRA regulatory region 8979

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to cytokine stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of glucose ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in pancreas development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pancreatic A cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of type B pancreatic cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to nicotine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in type B pancreatic cell maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein Nkx-6.1
Names
NK homeo box, family 6, member A
NK homeobox, family 6, A
NK6 transcription factor homolog A
NK6 transcription factor related, locus 1
homeobox protein NK-6 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006168.3NP_006159.2  homeobox protein Nkx-6.1

    See identical proteins and their annotated locations for NP_006159.2

    Status: VALIDATED

    Source sequence(s)
    AC096766
    Consensus CDS
    CCDS3607.1
    UniProtKB/Swiss-Prot
    P78426
    Related
    ENSP00000295886.3, ENST00000295886.5
    Conserved Domains (1) summary
    pfam00046
    Location:239293
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    84491985..84499292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    87821981..87829288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)