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CRHR2 corticotropin releasing hormone receptor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 482384, updated on 25-Jul-2026
Official Symbol
CRHR2provided by VGNC
Official Full Name
corticotropin releasing hormone receptor 2provided by VGNC
Primary source
VGNC:VGNC:39611
See related
Ensembl:ENSCAFG00845020144 RGD:12227584
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CRHR2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 14 NC_051818.1 (43307910..43355188, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 14 NC_006596.4 (42799432..42846743, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 14 NC_049235.1 (43461123..43508563, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 14 NC_049274.1 (43423758..43471041, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 14 NC_049755.1 (43099719..43147031, complement)

Chromosome 14 - NC_051818.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111098816 Neighboring gene gamma-glutamylcyclotransferase Neighboring gene glycyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC102153651 Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene uncharacterized LOC119867320

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables corticotrophin-releasing factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables corticotropin-releasing hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon terminus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
corticotropin-releasing factor receptor 2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051818.1 Reference ROS_Cfam_1.0

    Range
    43307910..43355188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038686854.1 → XP_038542782.1  corticotropin-releasing factor receptor 2 isoform X4

    Conserved Domains (2) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd15446
    Location:138 → 401
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  2. XM_038686858.1 → XP_038542786.1  corticotropin-releasing factor receptor 2 isoform X2

    Conserved Domains (3) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd14964
    Location:141 → 166
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:139 → 332
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_038686853.1 → XP_038542781.1  corticotropin-releasing factor receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JT57, A0A8I3PB95
    Related
    ENSCAFP00845027768.1, ENSCAFT00845035482.1
    Conserved Domains (2) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd15446
    Location:139 → 402
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  4. XM_038686855.1 → XP_038542783.1  corticotropin-releasing factor receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JTT8
    Conserved Domains (2) summary
    smart00008
    Location:60 → 131
    HormR; Domain present in hormone receptors
    cd15446
    Location:137 → 400
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  5. XM_038686857.1 → XP_038542785.1  corticotropin-releasing factor receptor 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3P1G6
    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    cd15446
    Location:112 → 375
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  6. XM_038686856.1 → XP_038542784.1  corticotropin-releasing factor receptor 2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0JUC7, A0A8I3P1G6, A0A8I3PCS7
    Related
    ENSCAFP00845027957.1, ENSCAFT00845035732.1
    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    cd15446
    Location:113 → 376
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049274.1 Alternate UMICH_Zoey_3.1

    Range
    43423758..43471041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038494964.1 → XP_038350892.1  

    Conserved Domains (2) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd15446
    Location:138 → 401
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  2. XM_038494969.1 → XP_038350897.1  

    Conserved Domains (3) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd14964
    Location:141 → 166
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:139 → 332
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_038494963.1 → XP_038350891.1  

    Conserved Domains (2) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd15446
    Location:139 → 402
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  4. XM_038494965.1 → XP_038350893.1  

    Conserved Domains (2) summary
    smart00008
    Location:60 → 131
    HormR; Domain present in hormone receptors
    cd15446
    Location:137 → 400
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  5. XM_038494967.1 → XP_038350895.1  

    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    cd15446
    Location:112 → 375
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  6. XM_038494966.1 → XP_038350894.1  

    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    cd15446
    Location:113 → 376
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  7. XM_038494968.1 → XP_038350896.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049755.1 Alternate UNSW_CanFamBas_1.0

    Range
    43099719..43147031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038621172.1 → XP_038477100.1  

  2. XM_038621171.1 → XP_038477099.1  

  3. XM_038621174.1 → XP_038477102.1  

    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    cd15446
    Location:112 → 375
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  4. XM_038621173.1 → XP_038477101.1  

    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    cd15446
    Location:113 → 376
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049235.1 Alternate UU_Cfam_GSD_1.0

    Range
    43461123..43508563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038557233.1 → XP_038413161.1  corticotropin-releasing factor receptor 2 isoform X4

    Conserved Domains (2) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd15446
    Location:138 → 401
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  2. XM_038557237.1 → XP_038413165.1  corticotropin-releasing factor receptor 2 isoform X2

    Conserved Domains (3) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd14964
    Location:141 → 166
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:139 → 332
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_038557232.1 → XP_038413160.1  corticotropin-releasing factor receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JT57, A0A8I3PB95
    Conserved Domains (2) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd15446
    Location:139 → 402
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  4. XM_038557234.1 → XP_038413162.1  corticotropin-releasing factor receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JTT8
    Conserved Domains (2) summary
    smart00008
    Location:60 → 131
    HormR; Domain present in hormone receptors
    cd15446
    Location:137 → 400
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  5. XM_038557236.1 → XP_038413164.1  corticotropin-releasing factor receptor 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3P1G6
    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    cd15446
    Location:112 → 375
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  6. XM_038557235.1 → XP_038413163.1  corticotropin-releasing factor receptor 2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0JUC7, A0A8I3P1G6, A0A8I3PCS7
    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    cd15446
    Location:113 → 376
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42799432..42846743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005628683.4 → XP_005628740.2  corticotropin-releasing factor receptor 2 isoform X4

    Conserved Domains (2) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd15446
    Location:138 → 401
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  2. XM_005628687.4 → XP_005628744.2  corticotropin-releasing factor receptor 2 isoform X2

    Conserved Domains (3) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd14964
    Location:141 → 166
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:139 → 332
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_005628682.4 → XP_005628739.2  corticotropin-releasing factor receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JT57, A0A8I3PB95
    Conserved Domains (2) summary
    smart00008
    Location:62 → 133
    HormR; Domain present in hormone receptors
    cd15446
    Location:139 → 402
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  4. XM_005628684.3 → XP_005628741.2  corticotropin-releasing factor receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JTT8
    Conserved Domains (2) summary
    smart00008
    Location:60 → 131
    HormR; Domain present in hormone receptors
    cd15446
    Location:137 → 400
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  5. XM_539501.6 → XP_539501.4  corticotropin-releasing factor receptor 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3P1G6
    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    cd15446
    Location:112 → 375
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

  6. XM_005628686.3 → XP_005628743.2  corticotropin-releasing factor receptor 2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0JUC7, A0A8I3P1G6, A0A8I3PCS7
    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    cd15446
    Location:113 → 376
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
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