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SMO smoothened, frizzled class receptor [ Canis lupus familiaris (dog) ]

Gene ID: 482262, updated on 17-Aug-2024

Summary

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Official Symbol
SMOprovided by VGNC
Official Full Name
smoothened, frizzled class receptorprovided by VGNC
Primary source
VGNC:VGNC:46565
See related
Ensembl:ENSCAFG00845020728
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 14 NC_051818.1 (7284734..7307875, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 14 NC_006596.4 (7206323..7229356, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 14 NC_049235.1 (7376821..7399952, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 14 NC_049274.1 (7489837..7512985, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 14 NC_049755.1 (7231685..7254904, complement)

Chromosome 14 - NC_051818.1Genomic Context describing neighboring genes Neighboring gene adenosylhomocysteinase like 2 Neighboring gene 60S ribosomal protein L12-like Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene tetraspanin 33 Neighboring gene uncharacterized LOC119867510

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables patched binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in commissural neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
smoothened homolog
Names
smoothened, frizzled family receptor
smoothened, seven transmembrane spanning receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051818.1 Reference ROS_Cfam_1.0

    Range
    7284734..7307875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038686174.1 → XP_038542102.1  smoothened homolog isoform X1

    UniProtKB/TrEMBL
    A0A8C0LA53, A0A8C0PCZ4, A0A8I3P5L7
    Related
    ENSCAFP00845028597.1, ENSCAFT00845036542.1
    Conserved Domains (2) summary
    cd07451
    Location:65 → 195
    CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
    cd15030
    Location:219 → 549
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

  2. XM_038686175.1 → XP_038542103.1  smoothened homolog isoform X2

    Conserved Domains (2) summary
    cd15030
    Location:90 → 420
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
    cl02447
    Location:1 → 66
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049274.1 Alternate UMICH_Zoey_3.1

    Range
    7489837..7512985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038494259.1 → XP_038350187.1  smoothened homolog isoform X1

    Conserved Domains (2) summary
    cd07451
    Location:65 → 195
    CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
    cd15030
    Location:219 → 549
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

  2. XM_038494260.1 → XP_038350188.1  smoothened homolog isoform X2

    Conserved Domains (2) summary
    cd15030
    Location:90 → 420
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
    cl02447
    Location:1 → 66
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049755.1 Alternate UNSW_CanFamBas_1.0

    Range
    7231685..7254904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038620488.1 → XP_038476416.1  smoothened homolog isoform X1

    Conserved Domains (2) summary
    cd07451
    Location:65 → 195
    CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
    cd15030
    Location:219 → 549
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

  2. XM_038620489.1 → XP_038476417.1  smoothened homolog isoform X2

    Conserved Domains (2) summary
    cd15030
    Location:90 → 420
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
    cl02447
    Location:1 → 66
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049235.1 Alternate UU_Cfam_GSD_1.0

    Range
    7376821..7399952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038556554.1 → XP_038412482.1  smoothened homolog isoform X1

    UniProtKB/TrEMBL
    A0A8C0LA53, A0A8C0PCZ4, A0A8I3P5L7
    Conserved Domains (2) summary
    cd07451
    Location:65 → 195
    CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
    cd15030
    Location:219 → 549
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

  2. XM_038556555.1 → XP_038412483.1  smoothened homolog isoform X2

    Conserved Domains (2) summary
    cd15030
    Location:90 → 420
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
    cl02447
    Location:1 → 66
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    7206323..7229356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038443356.1 → XP_038299284.1  smoothened homolog isoform X1

    UniProtKB/TrEMBL
    A0A8C0LA53, A0A8C0PCZ4, A0A8I3P5L7
    Conserved Domains (2) summary
    cd07451
    Location:65 → 195
    CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
    cd15030
    Location:219 → 549
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

  2. XM_038443362.1 → XP_038299290.1  smoothened homolog isoform X2

    Conserved Domains (2) summary
    cd15030
    Location:90 → 420
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
    cl02447
    Location:1 → 66
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
Nucleotide Protein
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