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MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like [ Canis lupus familiaris (dog) ]

Gene ID: 482197, updated on 25-Jul-2026
Official Symbol
MTHFD2Lprovided by VGNC
Official Full Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 likeprovided by VGNC
Primary source
VGNC:VGNC:51777
See related
Ensembl:ENSCAFG00845006423 RGD:12336584
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Try the new Gene page
Try the new Transcripts and proteins table
See MTHFD2L in Genome Data Viewer
Location:
chromosome: 13
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 13 NC_051817.1 (63497174..63632656)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 13 NC_006595.4 (62354053..62490793)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 13 NC_049234.1 (63734925..63872301)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 13 NC_049273.1 (63110477..63247437)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 13 NC_049754.1 (62593854..62729238)

Chromosome 13 - NC_051817.1Genomic Context describing neighboring genes Neighboring gene growth-regulated protein homolog gamma-like Neighboring gene uncharacterized LOC102154125 Neighboring gene probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 Neighboring gene uncharacterized LOC111098640 Neighboring gene epithelial mitogen Neighboring gene elongation factor 1-alpha 1-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables methenyltetrahydrofolate cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
Names
probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2-like
XP_022282803.1
XP_022282804.2
XP_022282807.1
XP_022282808.1
XP_022282809.1
XP_022282811.1
XP_022282812.1
XP_038288509.1
XP_038288510.1
XP_038349956.1
XP_038349957.1
XP_038349958.1
XP_038349960.1
XP_038349961.1
XP_038349962.1
XP_038349963.1
XP_038412247.1
XP_038412248.1
XP_038412249.1
XP_038412250.1
XP_038412251.1
XP_038412252.1
XP_038412253.1
XP_038476187.1
XP_038476188.1
XP_038476189.1
XP_038476190.1
XP_038476191.1
XP_038476192.1
XP_038541814.1
XP_038541815.1
XP_038541816.1
XP_038541817.1
XP_038541818.1
XP_038541819.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051817.1 Reference ROS_Cfam_1.0

    Range
    63497174..63632656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038685889.1 → XP_038541817.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X4

    Conserved Domains (1) summary
    COG0190
    Location:2 → 201
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_038685888.1 → XP_038541816.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X3

    Conserved Domains (1) summary
    COG0190
    Location:2 → 209
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  3. XM_038685887.1 → XP_038541815.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X2

    Conserved Domains (1) summary
    COG0190
    Location:2 → 253
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  4. XM_038685891.1 → XP_038541819.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X6

    Conserved Domains (1) summary
    COG0190
    Location:2 → 209
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  5. XM_038685886.1 → XP_038541814.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MUW9
    Related
    ENSCAFP00845008913.1, ENSCAFT00845011411.1
    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  6. XM_038685890.1 → XP_038541818.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X5

    Conserved Domains (1) summary
    COG0190
    Location:2 → 244
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

RNA

  1. XR_005436821.1 RNA Sequence

  2. XR_005436822.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049273.1 Alternate UMICH_Zoey_3.1

    Range
    63110477..63247437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038494029.1 → XP_038349957.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_038494028.1 → XP_038349956.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  3. XM_038494030.1 → XP_038349958.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 253
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  4. XM_038494035.1 → XP_038349963.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 209
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  5. XM_038494034.1 → XP_038349962.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 244
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  6. XM_038494033.1 → XP_038349961.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 201
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  7. XM_038494032.1 → XP_038349960.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 209
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

RNA

  1. XR_005335306.1 RNA Sequence

  2. XR_005335307.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049754.1 Alternate UNSW_CanFamBas_1.0

    Range
    62593854..62729238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038620262.1 → XP_038476190.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 201
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_038620261.1 → XP_038476189.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 209
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  3. XM_038620260.1 → XP_038476188.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 253
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  4. XM_038620264.1 → XP_038476192.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 209
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  5. XM_038620259.1 → XP_038476187.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  6. XM_038620263.1 → XP_038476191.1  

    Conserved Domains (1) summary
    COG0190
    Location:2 → 244
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

RNA

  1. XR_005403391.1 RNA Sequence

  2. XR_005403392.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049234.1 Alternate UU_Cfam_GSD_1.0

    Range
    63734925..63872301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038556320.1 → XP_038412248.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MUW9
    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_038556319.1 → XP_038412247.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MUW9
    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  3. XM_038556321.1 → XP_038412249.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X2

    Conserved Domains (1) summary
    COG0190
    Location:2 → 253
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  4. XM_038556325.1 → XP_038412253.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X6

    Conserved Domains (1) summary
    COG0190
    Location:2 → 209
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  5. XM_038556324.1 → XP_038412252.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X5

    Conserved Domains (1) summary
    COG0190
    Location:2 → 244
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  6. XM_038556323.1 → XP_038412251.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X4

    Conserved Domains (1) summary
    COG0190
    Location:2 → 201
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  7. XM_038556322.1 → XP_038412250.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X3

    Conserved Domains (1) summary
    COG0190
    Location:2 → 209
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

RNA

  1. XR_005369093.1 RNA Sequence

  2. XR_005369094.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006595.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    62354053..62490793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022427101.2 → XP_022282809.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MUW9
    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_022427104.2 → XP_022282812.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MUW9
    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  3. XM_022427100.2 → XP_022282808.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MUW9
    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  4. XM_022427099.1 → XP_022282807.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MUW9
    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  5. XM_022427103.2 → XP_022282811.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MUW9
    Conserved Domains (1) summary
    COG0190
    Location:2 → 286
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  6. XM_022427095.2 → XP_022282803.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X2

    Conserved Domains (1) summary
    COG0190
    Location:2 → 253
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  7. XM_038432582.1 → XP_038288510.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X6

    Conserved Domains (1) summary
    COG0190
    Location:2 → 209
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  8. XM_038432581.1 → XP_038288509.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X5

    Conserved Domains (1) summary
    COG0190
    Location:2 → 244
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  9. XM_022427096.2 → XP_022282804.2  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X3

    Conserved Domains (1) summary
    COG0190
    Location:2 → 209
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

RNA

  1. XR_005300235.1 RNA Sequence

  2. XR_002632717.1 RNA Sequence

Nucleotide Protein
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