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NKX2-2 NK2 homeobox 2 [ Homo sapiens (human) ]

Gene ID: 4821, updated on 20-Dec-2019

Summary

Official Symbol
NKX2-2provided by HGNC
Official Full Name
NK2 homeobox 2provided by HGNC
Primary source
HGNC:HGNC:7835
See related
Ensembl:ENSG00000125820 MIM:604612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKX2B; NKX2.2
Summary
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.1), stomach (RPKM 1.3) and 4 other tissues See more
Orthologs

Genomic context

See NKX2-2 in Genome Data Viewer
Location:
20p11.22
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (21511010..21514064, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (21491655..21494664, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2 Neighboring gene VISTA enhancer hs1205 Neighboring gene glutathione S-transferase mu 3 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1727 Neighboring gene long intergenic non-protein coding RNA 1726 Neighboring gene paired box 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
brain development TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
digestive tract development IEA
Inferred from Electronic Annotation
more info
 
endocrine pancreas development TAS
Traceable Author Statement
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
neuron fate specification IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
optic nerve development IEA
Inferred from Electronic Annotation
more info
 
pancreatic A cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
pancreatic PP cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
spinal cord motor neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
spinal cord oligodendrocyte cell fate specification IEA
Inferred from Electronic Annotation
more info
 
type B pancreatic cell development IEA
Inferred from Electronic Annotation
more info
 
type B pancreatic cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
ventral spinal cord interneuron fate determination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein Nkx-2.2
Names
NK2 transcription factor related, locus 2
NK2 transcription factor-like protein B
homeobox protein NK-2 homolog B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042186.1 RefSeqGene

    Range
    4963..8010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002509.4NP_002500.1  homeobox protein Nkx-2.2

    See identical proteins and their annotated locations for NP_002500.1

    Status: REVIEWED

    Source sequence(s)
    AL133325, BC075092, BU070383
    Consensus CDS
    CCDS13145.1
    UniProtKB/Swiss-Prot
    O95096
    Related
    ENSP00000366347.4, ENST00000377142.5
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    21511010..21514064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723566.3XP_006723629.1  homeobox protein Nkx-2.2 isoform X1

    Conserved Domains (2) summary
    COG5576
    Location:39146
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam00046
    Location:60113
    Homeobox; Homeobox domain
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