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PVALB parvalbumin [ Canis lupus familiaris (dog) ]

Gene ID: 481278, updated on 25-Jul-2026
Official Symbol
PVALBprovided by VGNC
Official Full Name
parvalbuminprovided by VGNC
Primary source
VGNC:VGNC:45214
See related
Ensembl:ENSCAFG00845008220 RGD:12275345
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See PVALB in Genome Data Viewer
Location:
chromosome: 10
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (28447846..28466434)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (27610209..27628586)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (28656677..28675084)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (28169344..28187929)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (28477867..28496446)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 4 Neighboring gene colony stimulating factor 2 receptor subunit beta Neighboring gene neutrophil cytosolic factor 4 Neighboring gene intraflagellar transport 27 Neighboring gene uncharacterized LOC111097658

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Parvalbumin alters mitochondrial dynamics and affects cell morphology. Lichvarova L, et al. Cell Mol Life Sci, 2018 Dec. PMID 30255402, Free PMC Article
  2. Parvalbumin expression in the claustrum of the adult dog. An immunohistochemical and topographical study with comparative notes on the structure of the nucleus. Pirone A, et al. J Chem Neuroanat, 2015 Mar-Apr. PMID 25724540
  3. Sustained expression of parvalbumin immunoreactivity in the hippocampal CA1 region and dentate gyrus during aging in dogs. Hwang IK, et al. Neurosci Lett, 2008 Mar 21. PMID 18280652
  4. Immunocytochemical localization of calcium-binding proteins, calbindin D28K-, calretinin-, and parvalbumin-containing neurons in the dog visual cortex. Yu SH, et al. Zoolog Sci, 2011 Sep. PMID 21882959
  5. Age-related changes in calbindin-D28k, parvalbumin, and calretinin immunoreactivity in the dog main olfactory bulb. Choi JH, et al. Cell Mol Neurobiol, 2010 Jan. PMID 19533334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Constitutive parvalbumin down-regulation in parvalbumin-overexpressing cells reverted mitochondrial morphology and fractional volume to the state present in control MDCK cells, resulting from increased mitochondrial movement and augmented fusion rates.
    Title: Parvalbumin alters mitochondrial dynamics and affects cell morphology.
  2. The topographical distribution of parvalbumin immunoreactivity suggests that the dog dorsal claustrum might be functionally related to the processing of visual inputs
    Title: Parvalbumin expression in the claustrum of the adult dog. An immunohistochemical and topographical study with comparative notes on the structure of the nucleus.
  3. This study elucidates the neurochemical structure of calcium-binding proteins which will be informative for the functional significance of different laminar distributions of calcium-binding proteins between species.
    Title: Immunocytochemical localization of calcium-binding proteins, calbindin D28K-, calretinin-, and parvalbumin-containing neurons in the dog visual cortex.
  4. Expression and age-related changes of calbindin-D28k (CB), parvalbumin (PV), and calretinin (CR) in the main olfactory bulb of the dog were investigated by immunohistochemistry and western blot analysis.
    Title: Age-related changes in calbindin-D28k, parvalbumin, and calretinin immunoreactivity in the dog main olfactory bulb.
  5. In 3-year-old dogs, PV immunoreactivity was higher in the CA1 region and dentate gyrus, and this was maintained in 10-year-old dogs. PV immunoreactive interneurons show resistance to age-dependent neurodegenerative processes.
    Title: Sustained expression of parvalbumin immunoreactivity in the hippocampal CA1 region and dentate gyrus during aging in dogs.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
parvalbumin alpha

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    28447846..28466434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038679967.1 → XP_038535895.1  parvalbumin alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0JV05
    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  2. XM_038679970.1 → XP_038535898.1  parvalbumin alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0JV05, A0A8I3N7Z7
    Related
    ENSCAFP00845011208.1, ENSCAFT00845014467.1
    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  3. XM_038679968.1 → XP_038535896.1  parvalbumin alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0JV05
    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  4. XM_038679966.1 → XP_038535894.1  parvalbumin alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0JV05
    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  5. XM_038679969.1 → XP_038535897.1  parvalbumin alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0JV05, A0A8I3N7Z7
    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    28169344..28187929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038488713.1 → XP_038344641.1  

    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  2. XM_038488716.1 → XP_038344644.1  

    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  3. XM_038488714.1 → XP_038344642.1  

    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  4. XM_038488712.1 → XP_038344640.1  

    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  5. XM_038488715.1 → XP_038344643.1  

    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    28477867..28496446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038614607.1 → XP_038470535.1  

    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  2. XM_038614610.1 → XP_038470538.1  

    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  3. XM_038614608.1 → XP_038470536.1  

    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  4. XM_038614606.1 → XP_038470534.1  

    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  5. XM_038614609.1 → XP_038470537.1  

    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    28656677..28675084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038550676.1 → XP_038406604.1  parvalbumin alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0JV05
    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  2. XM_038550680.1 → XP_038406608.1  parvalbumin alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0JV05, A0A8I3N7Z7
    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  3. XM_038550678.1 → XP_038406606.1  parvalbumin alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0JV05
    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  4. XM_038550675.1 → XP_038406603.1  parvalbumin alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0JV05
    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  5. XM_038550679.1 → XP_038406607.1  parvalbumin alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0JV05, A0A8I3N7Z7
    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    27610209..27628586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022424478.2 → XP_022280186.1  parvalbumin alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0JV05
    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  2. XM_003431505.4 → XP_003431553.1  parvalbumin alpha isoform X2

    See identical proteins and their annotated locations for XP_003431553.1

    UniProtKB/TrEMBL
    A0A8C0JV05, A0A8I3N7Z7
    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  3. XM_022424477.2 → XP_022280185.1  parvalbumin alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0JV05
    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  4. XM_022424476.2 → XP_022280184.1  parvalbumin alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0JV05
    Conserved Domains (1) summary
    cd16254
    Location:9 → 105
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  5. XM_538399.7 → XP_538399.2  parvalbumin alpha isoform X2

    See identical proteins and their annotated locations for XP_538399.2

    UniProtKB/TrEMBL
    A0A8C0JV05, A0A8I3N7Z7
    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin
Nucleotide Protein
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