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LRP1 LDL receptor related protein 1 [ Canis lupus familiaris (dog) ]

Gene ID: 481124, updated on 4-Nov-2022

Summary

Official Symbol
LRP1provided by VGNC
Official Full Name
LDL receptor related protein 1provided by VGNC
Primary source
VGNC:VGNC:42771
See related
Ensembl:ENSCAFG00845010106
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
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Genomic context

See LRP1 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
90
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (1270934..1352176)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (1324330..1405506)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (1614746..1695694)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (1247639..1328819)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (1489631..1570787)
105 previous assembly CanFam3.1 (GCF_000002285.3) 10 NC_006592.3 (1260256..1341705)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene nuclear envelope integral membrane protein 1 Neighboring gene NGFI-A binding protein 2 Neighboring gene signal transducer and activator of transcription 6 Neighboring gene uncharacterized LOC119873570 Neighboring gene uncharacterized LOC102156850 Neighboring gene neurexophilin 4 Neighboring gene serine hydroxymethyltransferase 2

Genomic regions, transcripts, and products

Pathways from PubChem

General protein information

Preferred Names
prolow-density lipoprotein receptor-related protein 1; LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1
Names
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    1270934..1352176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038679069.1XP_038534997.1  prolow-density lipoprotein receptor-related protein 1 isoform X1

    Conserved Domains (10) summary
    smart00192
    Location:35103543
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:31113153
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:29993028
    EGF_CA; Calcium-binding EGF-like domain
    COG3386
    Location:22702480
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cd00112
    Location:35923626
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:28742908
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:40304070
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:29793002
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:807842
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:71104
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  2. XM_038679070.1XP_038534998.1  prolow-density lipoprotein receptor-related protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3N9S8
    Related
    ENSCAFP00845013914.1, ENSCAFT00845017864.1
    Conserved Domains (10) summary
    smart00192
    Location:34933526
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:30943136
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:29823011
    EGF_CA; Calcium-binding EGF-like domain
    COG3386
    Location:22532463
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cd00112
    Location:35753609
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:28572891
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:40134053
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:29622985
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:807842
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:71104
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    1247639..1328819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487853.1XP_038343781.1  prolow-density lipoprotein receptor-related protein 1 isoform X1

  2. XM_038487854.1XP_038343782.1  prolow-density lipoprotein receptor-related protein 1 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    1489631..1570787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038613707.1XP_038469635.1  prolow-density lipoprotein receptor-related protein 1 isoform X1

  2. XM_038613708.1XP_038469636.1  prolow-density lipoprotein receptor-related protein 1 isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    1614746..1695694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038549747.1XP_038405675.1  LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1 isoform X2

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    1324330..1405506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022424083.2XP_022279791.1  prolow-density lipoprotein receptor-related protein 1 isoform X1

    Conserved Domains (10) summary
    smart00192
    Location:35103543
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:31113153
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:29993028
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:35923626
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:28742908
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:40304070
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl00104
    Location:71104
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam12662
    Location:29793002
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:807842
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl26742
    Location:22702480
    SGL; SMP-30/Gluconolaconase/LRE-like region
  2. XM_538245.7XP_538245.4  prolow-density lipoprotein receptor-related protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MZ75, A0A8P0S657, J9P315
    Conserved Domains (10) summary
    smart00192
    Location:34933526
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:30943136
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:29823011
    EGF_CA; Calcium-binding EGF-like domain
    COG3386
    Location:22532463
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cd00112
    Location:35753609
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:28572891
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:40134053
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:29622985
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:807842
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:71104
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...