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Su(z)12 Su(z)12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48071, updated on 4-Feb-2026
Official Symbol
Su(z)12provided by FlyBase
Official Full Name
Su(z)12provided by FlyBase
Primary source
FLYBASE:FBgn0020887
Locus tag
Dmel_CG8013
See related
AllianceGenome:FB:FBgn0020887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8013; Dmel\CG8013; l(3)76BDo; Su(z); su(z)12; Su(Z)12; SU(Z)12; Su(z)[12]; Suz(12); Suz12; SUZ12
Summary
Contributes to nucleosome binding activity. Involved in negative regulation of response to gamma radiation and neurogenesis. Located in nucleus. Part of ESC/E(Z) complex. Is expressed in organism. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Su(z)12 in Genome Data Viewer
Location:
76D4-76D4; 3-46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19918242..19923462, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19911342..19916562, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Precursor RNA processing 3 Neighboring gene Mtr3 Neighboring gene Regulatory particle non-ATPase 1 Neighboring gene Prefoldin 6 Neighboring gene Grasp65

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. General transcriptional silencing by a Polycomb response element in Drosophila. Sengupta AK, et al. Development, 2004 May. PMID 15056613
  2. Multidimensional Proteomics Identifies Declines in Protein Homeostasis and Mitochondria as Early Signals for Normal Aging and Age-associated Disease in Drosophila. Yang L, et al. Mol Cell Proteomics, 2019 Oct. PMID 31434710, Free PMC Article
  3. In vivo antagonistic role of the Human T-Cell Leukemia Virus Type 1 regulatory proteins Tax and HBZ. Akkouche A, et al. PLoS Pathog, 2021 Jan. PMID 33471856, Free PMC Article
  4. Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core. Sharaf A, et al. Life Sci Alliance, 2022 Jul. PMID 35440471, Free PMC Article
  5. Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Birve A, et al. Development, 2001 Sep. PMID 11546753

See all (207) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chracterization of functionally critical SU(Z)12 elements, including key determinants of SU(Z)12-E(Z) communication.
    Title: Elements of the polycomb repressor SU(Z)12 needed for histone H3-K27 methylation, the interface with E(Z), and in vivo function.
  2. Chromatin-modifying complex component Nurf55/p55 associates with histones H3 and H4 and polycomb repressive complex 2 subunit Su(z)12 through partially overlapping binding sites.
    Title: Chromatin-modifying complex component Nurf55/p55 associates with histones H3 and H4 and polycomb repressive complex 2 subunit Su(z)12 through partially overlapping binding sites.
  3. Data show that SU(Z)12 and Heterochromatin Protein 1 (HP1) do not co-localize.
    Title: In vivo analysis of Drosophila SU(Z)12 function.
  4. A Pcl-PSC2 complex is the histone methyltransferase that generates the high levels of histone3-lysine27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state.
    Title: Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes.
  5. The nucleosome-binding subunits Su(z)12 and Nurf55 anchor the E(z) enzyme on chromatin substrates, an essential process in maintaining HOX gene silencing during development.
    Title: Nucleosome binding and histone methyltransferase activity of Drosophila PRC2.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to nucleosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in facultative heterochromatin formation IC
Inferred by Curator
more info
 PubMed 
involved_in heterochromatin formation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RSC-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Su(z)12
Names
CG8013-PA
CG8013-PB
Su(z)12-PA
Su(z)12-PB
Suppressor-of-zeste-12
suppressor of zeste
suppressor of zeste 12

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19918242..19923462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168826.2 → NP_730465.1  Su(z)12, isoform B

    See identical proteins and their annotated locations for NP_730465.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T9D8, Q9NJG9, Q9VW55
    Related
    FBpp0074686
    Conserved Domains (1) summary
    pfam09733
    Location:511 → 644
    VEFS-Box; VEFS-Box of polycomb protein

  2. NM_143802.3 → NP_652059.1  Su(z)12, isoform A

    See identical proteins and their annotated locations for NP_652059.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NJG9
    Related
    FBpp0074685
    Conserved Domains (1) summary
    pfam09733
    Location:511 → 644
    VEFS-Box; VEFS-Box of polycomb protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NJG9.1 Q9NJG9

Gene LinkOut

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