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RARA retinoic acid receptor alpha [ Canis lupus familiaris (dog) ]

Gene ID: 480526, updated on 17-Aug-2024

Summary

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Official Symbol
RARAprovided by VGNC
Official Full Name
retinoic acid receptor alphaprovided by VGNC
Primary source
VGNC:VGNC:45351
See related
Ensembl:ENSCAFG00845008607
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
HS-RARa
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (23046731..23091126, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (21727250..21761701, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (22205221..22239665, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (21821642..21856078, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (22080340..22114785, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa pseudogene Neighboring gene DNA topoisomerase II alpha Neighboring gene uncharacterized LOC102153525 Neighboring gene gap junction protein delta 3 Neighboring gene U6 spliceosomal RNA Neighboring gene cell division cycle 6 Neighboring gene WAS/WASL interacting protein family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a canine highly similar to retinoic acid receptor alpha. Miyajima N, et al. DNA Seq, 2005 Feb. PMID 16040341
  2. Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5. Werner P, et al. Genomics, 1997 May 15. PMID 9177778
  3. Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors. Waxman JS, et al. Dev Dyn, 2007 Feb. PMID 17195188

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cloning and gene expression
    Title: Identification and characterization of a canine highly similar to retinoic acid receptor alpha.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear glucocorticoid receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to corticotropin-releasing hormone stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
retinoic acid receptor alpha
Names
RAR-alpha
nuclear receptor subfamily 1 group B member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012645.1 → NP_001012663.1  retinoic acid receptor alpha

    See identical proteins and their annotated locations for NP_001012663.1

    Status: PROVISIONAL

    Source sequence(s)
    AB179779
    UniProtKB/Swiss-Prot
    Q5FBR4
    Related
    ENSCAFP00845011756.1, ENSCAFT00845015144.1
    Conserved Domains (2) summary
    cd06937
    Location:186 → 416
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:82 → 166
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    23046731..23091126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038675020.1 → XP_038530948.1  retinoic acid receptor alpha isoform X3

    Conserved Domains (1) summary
    cd06937
    Location:142 → 372
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

  2. XM_038675018.1 → XP_038530946.1  retinoic acid receptor alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NET5, A0A8C0R3R3, A0A8I3MYI9
    Conserved Domains (2) summary
    cd06937
    Location:186 → 416
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:82 → 166
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

  3. XM_038675021.1 → XP_038530949.1  retinoic acid receptor alpha isoform X4

    Conserved Domains (2) summary
    cd06937
    Location:138 → 368
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:34 → 118
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

  4. XM_038675019.1 → XP_038530947.1  retinoic acid receptor alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0PP63, A0A8C0R3L1, A0A8I3N8T8
    Related
    ENSCAFP00845011834.1, ENSCAFT00845015238.1
    Conserved Domains (2) summary
    cd06937
    Location:183 → 413
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:79 → 163
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

  5. XM_038675022.1 → XP_038530950.1  retinoic acid receptor alpha isoform X5

    Conserved Domains (2) summary
    cd06937
    Location:133 → 363
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:29 → 113
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    21821642..21856078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    22080340..22114785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    22205221..22239665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21727250..21761701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FBR4.1 GenPept UniProtKB/Swiss-Prot:Q5FBR4

Gene LinkOut

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Molecular Biology Databases
Research Materials