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NGFR nerve growth factor receptor [ Homo sapiens (human) ]

Gene ID: 4804, updated on 16-Feb-2020

Summary

Official Symbol
NGFRprovided by HGNC
Official Full Name
nerve growth factor receptorprovided by HGNC
Primary source
HGNC:HGNC:7809
See related
Ensembl:ENSG00000064300 MIM:162010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
Summary
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 11.7), adrenal (RPKM 11.6) and 20 other tissues See more
Orthologs

Genomic context

See NGFR in Genome Data Viewer
Location:
17q21.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (49495293..49515008)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47572655..47592382)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2075 Neighboring gene uncharacterized LOC100288866 Neighboring gene microRNA 6165 Neighboring gene neurexophilin 3 Neighboring gene uncharacterized LOC107984999 Neighboring gene speckle type BTB/POZ protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of nerve growth factor receptor is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
amyloid-beta binding TAS
Traceable Author Statement
more info
PubMed 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
death receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
death receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
nerve growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nerve growth factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
neurotrophin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
cellular glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to amyloid-beta IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane protein intracellular domain proteolysis TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 
negative regulation of axonogenesis TAS
Traceable Author Statement
more info
 
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of axonogenesis TAS
Traceable Author Statement
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
endosome TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 16
Names
NGF receptor
TNFR superfamily, member 16
low affinity neurotrophin receptor p75NTR
low-affinity nerve growth factor receptor
p75 ICD

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002507.4NP_002498.1  tumor necrosis factor receptor superfamily member 16 precursor

    See identical proteins and their annotated locations for NP_002498.1

    Status: REVIEWED

    Source sequence(s)
    BQ639556, CK299927, DA115173, M14764
    Consensus CDS
    CCDS11549.1
    UniProtKB/Swiss-Prot
    P08138
    Related
    ENSP00000172229.3, ENST00000172229.8
    Conserved Domains (2) summary
    cd08311
    Location:340418
    Death_p75NR; Death domain of p75 Neurotrophin Receptor
    cd13416
    Location:30188
    TNFRSF16; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    49495293..49515008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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